Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline

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dc.authorid0000-0001-5993-1668en_US
dc.authorid0000-0002-5650-1280
dc.authorid0000-0002-2443-2372
dc.contributor.authorGülçin, İlhami
dc.contributor.authorElias, Riad
dc.contributor.authorGepdiremen, Akçahan
dc.contributor.authorChea, Aun
dc.contributor.authorTopal, Fevzi
dc.date.accessioned2021-06-23T19:27:12Z
dc.date.available2021-06-23T19:27:12Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIn the present study, we determined the antioxidant activity of cepharanthine and fangchinoline from Stephania rotunda by performing different in vitro antioxidant assays, including 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging, N,N-dimethyl-p-phenylenediamine dihydrochloride (DMPD) radical scavenging, superoxide anion (O-2(center dot-)) radical scavenging, hydrogen peroxide scavenging, total antioxidant activity, reducing power, and ferrous ion (Fe2+) chelating activities. Cepharanthine and fangchinoline showed 94.6 and 93.3% inhibition on lipid peroxidation of linoleic acid emulsion at 30 mu g/mL concentration, respectively. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox indicated inhibitions of 83.3, 92.2, 72.4, and 81.3% on peroxidation of linoleic acid emulsion at the same concentration (30 mu g/mL), respectively. According to the results, cepharanthine and fangchinoline have effective antioxidant and radical scavenging activity.en_US
dc.identifier.doi10.3109/14756360902932792
dc.identifier.endpage53en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue1en_US
dc.identifier.pmid20030508en_US
dc.identifier.scopus2-s2.0-74349130587en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage44en_US
dc.identifier.urihttps://doi.org/10.3109/14756360902932792
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6761
dc.identifier.volume25en_US
dc.identifier.wosWOS:000275000900006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGepdiremen, Akçahan
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Enzyme Inhibition And Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant Activityen_US
dc.subjectCepharanthineen_US
dc.subjectFangchinolineen_US
dc.subjectStephania Rotundaen_US
dc.subjectAlkaloiden_US
dc.subjectRadical Scavengingen_US
dc.titleAntioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinolineen_US
dc.typeArticleen_US

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