Treatment in carbon monoxide poisoning patients with headache: a prospective, multicenter, double-blind, controlled clinical trial

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dc.authorid0000-0002-2119-9448
dc.authorid0000-0002-6158-0286
dc.contributor.authorOcak, Tarık
dc.contributor.authorTekin, Erdal
dc.contributor.authorBaştürk, Mustafa
dc.contributor.authorDuran, Arif
dc.contributor.authorSerinken, Mustafa
dc.date.accessioned2021-06-23T19:42:53Z
dc.date.available2021-06-23T19:42:53Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: There is a lack of specificity of the analgesic agents used to treat headache and underlying acute carbon monoxide poisoning. Objective: To compare effectiveness of "oxygen alone" vs "metoclopramide plus oxygen" vs "metamizole plus oxygen" therapy in treating carbon monoxide-induced headache. Design: A prospective, multicenter, double-blind, controlled trial. Setting: Three emergency departments in Turkey. Population: Adult carbon monoxide poisoning patients with headache. Methods: A total of 117 carbon monoxide-intoxicated patients with headache were randomized into 3 groups and assessed at baseline, 30 minutes, 90 minutes, and 4 hours. Main Outcome Measure: The primary outcomewas patient-reported improvement rates for headache. Secondary end points included nausea, need for rescue medication during treatment, and reduction in carboxyhemoglobin levels. Results: During observation, there was no statistical difference between drug type and visual analog scale score change at 30 minutes, 90 minutes, or 4 hours, for either headache or nausea. No rescue medication was needed during the study period. The reduction in carboxyhemoglobin levels did not differ among the 3 groups. Conclusion: The use of "oxygen alone" is as efficacious as "oxygen plus metoclopramide" or "oxygen plus metamizole sodium" in the treatment of carbon monoxide-induced headache. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.ajem.2016.08.002
dc.identifier.endpage2145en_US
dc.identifier.issn0735-6757
dc.identifier.issn1532-8171
dc.identifier.issue11en_US
dc.identifier.pmid27553827en_US
dc.identifier.scopus2-s2.0-84994157132en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2140en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2016.08.002
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8633
dc.identifier.volume34en_US
dc.identifier.wosWOS:000389517200016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDuran, Arif
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon Monoxideen_US
dc.subjectClinical Trial
dc.titleTreatment in carbon monoxide poisoning patients with headache: a prospective, multicenter, double-blind, controlled clinical trialen_US
dc.typeArticleen_US

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