Carvacrol attenuates histopathogic and functional impairments induced by bilateral renal ischemia/reperfusion in rats

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dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-9277-9119
dc.authorid0000-0001-6768-1275
dc.authorid0000-0001-5608-5742
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorTekçe, Buket Kın
dc.contributor.authorÖztürk, Hayrettin
dc.date.accessioned2021-06-23T19:49:58Z
dc.date.available2021-06-23T19:49:58Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Renal ischemia/reperfusion injury is the most common cause of acute kidney injury, which frequent occurrence in critically ill patients. Objectives: The aim of this study was to investigate the role of Carvacrol (CARV) against bilateral ischemia reperfusion (I/R) in rats. Methods: Renal I/R injury were induced by clamping of the left and right renal arteries for 45 min followed by 24 h of reperfusion. Thirty male Sprague-Dawley rats were randomly allocated to three groups (n = 10): the sham-control group, the renal I/R-untreated (I/R-untreated) group, and the I/R- CARV-treated group. At 2 h before reperfusion, the rats in the I/R- CARV - treated group rats received an i.p. injection of 75 mg/kg CARV. Renal function and histological changes were compared and the relevant parameters of oxidative stress and inflammation were detected. Results: Compared to the sham-control group, I/R led to renal dysfunction as evidenced by higher plasma urea and creatinine along with increase in oxidative stress and histological changes in renal tissues. Treatment with CARV decreased urea, creatinine, and renal MDA and MPO levels, and increased SOD, CAT, GSH activity and eNOS expression in the kidney. In the I/R-CARV-treated group, minimal hydropic changes in the tubular epithelial cells and regeneration of tubular epithelium were observed. Conclusion: These results suggest that CARV treatment could reduce renal injury induced by bilateral renal I/R via anti-inflammatory, antioxidant and cytoprotective effects.en_US
dc.identifier.doi10.1016/j.biopha.2017.12.060
dc.identifier.endpage661en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid29291552en_US
dc.identifier.scopus2-s2.0-85039739564en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage656en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2017.12.060
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9667
dc.identifier.volume98en_US
dc.identifier.wosWOS:000426104000081en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Hülya
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorDüzcü, Selma Erdoğan
dc.institutionauthorTekçe, Buket Kın
dc.institutionauthorÖztürk, Hayrettin
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBilateral Renal Ischemiaen_US
dc.titleCarvacrol attenuates histopathogic and functional impairments induced by bilateral renal ischemia/reperfusion in ratsen_US
dc.typeArticleen_US

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