Mood scores in relation to hormone replacement therapies during menopause: a prospective randomized trial

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dc.authorid0000-0003-4478-7514en_US
dc.authorid0000-0003-3446-3751en_US
dc.authorid0000-0002-3856-3787en_US
dc.authorid0000-0002-8929-6973
dc.contributor.authorÖnalan, Göğşen
dc.contributor.authorÖnalan, Reşide
dc.contributor.authorSelam, Belgin
dc.contributor.authorAkar, Münire
dc.contributor.authorGünenç, Ziya
dc.contributor.authorTopçuoğlu, Ata
dc.date.accessioned2021-06-23T19:18:09Z
dc.date.available2021-06-23T19:18:09Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThere is lack of studies in literature about the long-term effects of hormone replacement therapies and cholesterol levels on mood scores in menopause. In the present study we have investigated whether serum lipid levels affect mood scores in menopause and evaluated the long-term effects of the combined hormone replacement regimens (HRT) on depressive symptoms in postmenopausal women. In this prospective-randomized, placebo-controlled, double-blind study, 286 women in menopause were divided into four groups according to therapeutic regimens they received; 1) Conjugated equine estrogen (CEE) of 0.625 mg plus medroxyprogesterone acetate (MPA) of 2.5 mg (n = 79), 2) CEE (0.625 mg) plus MPA of 5 mg (n = 77), 3) tibolone of 2.5 mg (a selective tissue estrogenic activity regulator) (n = 76), and 4) Calcium (Ca) of 1,000 mg (n = 54). Beck Depression Inventory (BDI), and serum levels of lipoprotein lipids were assessed before and after 12-months of treatment with oral continuous HRT and Ca supplementation. BDI scores in the study groups were not correlated with lipid profiles. We compared two subgroups of patients with initial BDI scores 0-14 (normal mood scores) in order to asses for the possible relation between the lipid profile and mood. Following treatment, first subgroup had increased scores to 15-30 (mildly depressed women, n = 27) and the second subgroup preserved BDI scores of 0-14 (normal mood scores, n = 23). Serum levels of total cholesterol, high-density lipoprotein, low-density lipoprotein and body mass index were found to be similar between these two groups. BDI scores decreased significantly in all HRT groups after 12 months of treatment, compared to Ca group (p < 0.05). We did not observe any correlation between BDI scores and lipid profiles before and following continuous HRT or Ca supplementation. Continuous combined hormone replacement regimens, CEE + MPA and tibolone, have superior long-tenn effects on mood scores in menopause and should be considered during the decision process for use of HRT due to menopausal symptoms.en_US
dc.identifier.doi10.1620/tjem.207.223
dc.identifier.endpage231en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue3en_US
dc.identifier.pmid16210834en_US
dc.identifier.scopus2-s2.0-27744525518en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.207.223
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5656
dc.identifier.volume207en_US
dc.identifier.wosWOS:000232286600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSelam, Belgin
dc.institutionauthorTopçuoğlu, Ata
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal Of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMenopauseen_US
dc.subjectCholesterolen_US
dc.subjectDepressionen_US
dc.subjectHRTen_US
dc.titleMood scores in relation to hormone replacement therapies during menopause: a prospective randomized trialen_US
dc.typeArticleen_US

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