Elevated neutrophil/lymphocyte ratio in patients with schizophrenia

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dc.authorid0000-0001-8401-4992
dc.contributor.authorSemiz, Murat
dc.contributor.authorYıldırım, Osman
dc.contributor.authorCanan, Fatih
dc.contributor.authorDemir, Süleyman
dc.contributor.authorHasbek, Ekrem
dc.contributor.authorTuman, Taha Can
dc.contributor.authorKayka, Nefise
dc.date.accessioned2021-06-23T19:37:07Z
dc.date.available2021-06-23T19:37:07Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Inflammatory mechanisms are reported to play important roles in the pathophysiology of schizophrenia. The neutrophil-lymphocyte ratio (NLR) is a simple and easily accessible indicator of the systemic inflammatory response. Our goal was to investigate whether NLR was higher in patients with schizophrenia than in healthy comparison subjects similar in age, sex, and body mass index. Subjects and methods: In this multicenter cross-sectional study, we analyzed 156 non-obese patients with schizophrenia and 89 healthy control subjects for complete blood count. The Brief Psychiatric Rating Scale was used to determine the severity of clinical pathology. Results: The mean +/- SD NLR of patients with schizophrenia was significantly higher than that of healthy controls (2.6 +/- 1.1 vs. 1.9 +/- 0.6, respectively, p<0.001). NLR did not significantly correlate with severity and duration of schizophrenia (r=0.065. p>0.05). Conclusions: Our findings suggest that NLR levels are increased in physically healthy, non-obese, patients with schizophrenia when compared with physically and mentally healthy individuals. To our knowledge, this is the first study that demonstrated the association between NLR and schizophrenia.en_US
dc.identifier.endpage225en_US
dc.identifier.issn0353-5053
dc.identifier.issue3en_US
dc.identifier.pmid25191768en_US
dc.identifier.scopus2-s2.0-84907161027en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8110
dc.identifier.urihttps://hrcak.srce.hr/file/239115
dc.identifier.volume26en_US
dc.identifier.wosWOS:000346147300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYıldırım, Osman
dc.institutionauthorKayka, Nefise
dc.institutionauthorTuman, Taha Can
dc.language.isoenen_US
dc.publisherMedicinska Nakladaen_US
dc.relation.ispartofPsychiatria Danubinaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLymphocyteen_US
dc.subjectNeutrophilen_US
dc.subjectNeutrophil/lymphocyte Ratioen_US
dc.subjectSchizophreniaen_US
dc.subjectInflammationen_US
dc.subjectImmunologyen_US
dc.titleElevated neutrophil/lymphocyte ratio in patients with schizophreniaen_US
dc.typeArticleen_US

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