The relationship of paraoxonase 1 activity with lipid metabolism in obese women
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gazi Universitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The aim of this study was to identify the effects of serum lipids, apolipoprotein (apo) A-I, apo B and paraoxonase/arylesterase (PON1) activity on obesity in women. Methods: The study was conducted on 90 subjects categorized into three groups; there were 30 women in each group with an age range of 18-48 years. Group 1 had 30 abdominal obese patients, group 2 had 30 gynoid obeses and group 3 included 30 healthy control subjects. Results: There was a statistically significant difference between the triglyceride, high-density lipoprotein cholesterol (HDL-C), apo B, direct low-density lipoprotein cholesterol (D-LDL-C), high sensitive-CRP (hsCRP), homeostasis model insulin resistance (HOMA-IR) levels of group 1 and 2 (p=0.001, p<0.0001, p=0.016, p=0.001, p<0.0001, p<0.0001, respectively). For HDL-C, D-LDL-C, hsCRP and HOMA-IR levels, there were statistically significant differences between group 1 and 3 (p=0.023, p=0.023, p<0.0001, p=0.001, respectively). Triglyceride, apo B, HDL-C, D-LDL-C parameters differed significantly in abdominal obesity, whereas there was no difference among the groups for PON1 activity. Conclusion: Our results indicate that lipid metabolism is altered in obesity, but PON1 activity appears not to be affected.
Açıklama
Anahtar Kelimeler
Lipid Metabolism, Obesity, Paraoxonase 1
Kaynak
Gazi Medical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
25
Sayı
1
