The relationship of paraoxonase 1 activity with lipid metabolism in obese women

dc.authorid0000-0002-4060-3354
dc.contributor.authorÖzcan, Fatih
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorSerin, Erdinç
dc.contributor.authorTosun, Mehmet
dc.date.accessioned2021-06-23T18:55:16Z
dc.date.available2021-06-23T18:55:16Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The aim of this study was to identify the effects of serum lipids, apolipoprotein (apo) A-I, apo B and paraoxonase/arylesterase (PON1) activity on obesity in women. Methods: The study was conducted on 90 subjects categorized into three groups; there were 30 women in each group with an age range of 18-48 years. Group 1 had 30 abdominal obese patients, group 2 had 30 gynoid obeses and group 3 included 30 healthy control subjects. Results: There was a statistically significant difference between the triglyceride, high-density lipoprotein cholesterol (HDL-C), apo B, direct low-density lipoprotein cholesterol (D-LDL-C), high sensitive-CRP (hsCRP), homeostasis model insulin resistance (HOMA-IR) levels of group 1 and 2 (p=0.001, p<0.0001, p=0.016, p=0.001, p<0.0001, p<0.0001, respectively). For HDL-C, D-LDL-C, hsCRP and HOMA-IR levels, there were statistically significant differences between group 1 and 3 (p=0.023, p=0.023, p<0.0001, p=0.001, respectively). Triglyceride, apo B, HDL-C, D-LDL-C parameters differed significantly in abdominal obesity, whereas there was no difference among the groups for PON1 activity. Conclusion: Our results indicate that lipid metabolism is altered in obesity, but PON1 activity appears not to be affected.en_US
dc.identifier.doi10.12996/gmj.2014.03
dc.identifier.endpage15en_US
dc.identifier.issn2147-2092
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84940230851en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.12996/gmj.2014.03
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4727
dc.identifier.volume25en_US
dc.identifier.wosWOS:000217468400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorTosun, Mehmet
dc.language.isoenen_US
dc.publisherGazi Universitesien_US
dc.relation.ispartofGazi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLipid Metabolismen_US
dc.subjectObesityen_US
dc.subjectParaoxonase 1en_US
dc.titleThe relationship of paraoxonase 1 activity with lipid metabolism in obese womenen_US
dc.typeArticleen_US

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