Effect of decorin and bevacizumab on oxygen-induced retinopathy in rat models: a comparative study

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dc.authorid0000-0003-4468-3985
dc.authorid0000-0002-1666-6777
dc.authorid0000-0003-1337-459X
dc.authorid0000-0003-1364-4684
dc.authorid0000-0001-7736-402X
dc.authorid0000-0001-5962-8810
dc.contributor.authorGüler, Seda Duran
dc.contributor.authorBalbaba, Mehmet
dc.contributor.authorÇolakoğlu, Neriman
dc.contributor.authorBulmuş, Özgür
dc.contributor.authorUlaş, Fatih
dc.contributor.authorEröksüz, Yesari
dc.date.accessioned2021-06-23T18:57:06Z
dc.date.available2021-06-23T18:57:06Z
dc.date.issued2021
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The aims of this study were to evaluate the effects of decorin (DCN) in rat oxygen-induced retinopathy (OIR) model and to compare the results with those of bevacizumab. Methods: Twenty-eight newborn Sprague-Dawley rats were randomly divided into four groups. Group I (control): normoxia plus intraperitoneal (ip) normal saline (NS), Group II (sham): OIR plus ip NS, Group III (DCN): OIR plus ip 0.1 mg/kg DCN, and Group IV (bevacizumab): OIR plus ip 2.5 mg/kg bevacizumab. The OIR model was induced by cycling the oxygen concentration between 50% and 10% every 24 h for 14 days following their birth. In all groups, injections were administered on postnatal day (PD) 15. All animals were sacrificed and their right eyes were enucleated on PD 18. The nuclei of neovascular endothelial cells on the vitreal side of the inner limiting membrane were counted, and vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF)-? immunoreactivity were detected in histopathological and immunohistochemical examinations. One-way analysis of variance and post hoc Tukey tests were used for statistical analyses of the data. Results: In Groups II, III, and IV, the mean neovascular cell nuclei counts were 13.14 ± 1.34, 6.57 ± 1.51, and 6.71 ± 1.49, respectively. The mean neovascular cell nuclei count was significantly reduced in treatment groups compared with sham group (P < 0.001). In immunohistochemical staining, the immunoreactivity of VEGF was 0.07 ± 0.02, 0.97 ± 0.21, 0.37 ± 0.12, and 0.23 ± 0.17, respectively. Likewise, immunoreactivity of TNF-? was 0.02 ± 0.02, 1.11 ± 0.36, 0.37 ± 0.13, and 0.62 ± 0.21, respectively. VEGF and TNF-? immunoreactivity increased markedly in the sham group compared with those in the control group (P < 0.001). VEGF and TNF-? immunoreactivity of treatment groups decreased significantly compared to sham group (P < 0.001). Conclusion: The beneficial effects obtained by DCN administration in OIR model were comparable to the effects of bevacizumab.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Management Unit, FÜBAP: TF.19.05en_US
dc.description.sponsorshipFinancial support was received from Fırat University Scientific Research Project Center (FÜBAP) for this submission (Project no: TF.19.05).en_US
dc.description.sponsorshipFinancial support was received from Firat University Scientific Research Project Center (FUBAP) for this submission (Project no: TF.19.05).
dc.identifier.doi10.4103/ijo.IJO_1739_20
dc.identifier.endpage373en_US
dc.identifier.issn0301-4738
dc.identifier.issue2en_US
dc.identifier.pmid33463595en_US
dc.identifier.scopus2-s2.0-85099961632en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://doi.org/10.4103/ijo.IJO_1739_20
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5131
dc.identifier.volume69en_US
dc.identifier.wosWOS:000613563700038en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlaş, Fatih
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Ophthalmologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBevacizumaben_US
dc.subjectDecorinen_US
dc.subjectOxygen-Induced Retinopathyen_US
dc.subjectRetinopathy of Prematurityen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.titleEffect of decorin and bevacizumab on oxygen-induced retinopathy in rat models: a comparative studyen_US
dc.typeReview Articleen_US

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