A retrospective multicenter evaluation of cutaneous melanomas in Turkey

Basit Öğe Kaydı
dc.authorid0000-0002-3045-9942en_US
dc.authorid0000-0001-9942-4898en_US
dc.authorid0000-0003-0472-4826en_US
dc.authorid0000-0003-0059-3822
dc.authorid0000-0002-6553-4500
dc.contributor.authorGamsızkan, Mehmet
dc.contributor.authorYılmaz, İsmail
dc.contributor.authorBüyükbabani, Nesimi
dc.contributor.authorDemirkesen, Cuyan
dc.contributor.authorDemiriz, Murat
dc.contributor.authorAstarcı, Hesna Müzeyyen
dc.date.accessioned2021-06-23T19:36:33Z
dc.date.available2021-06-23T19:36:33Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), >= 6/mm(2) mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.en_US
dc.identifier.doi10.7314/APJCP.2014.15.23.10451
dc.identifier.endpage10456en_US
dc.identifier.issn1513-7368
dc.identifier.issue23en_US
dc.identifier.pmid25556491en_US
dc.identifier.scopus2-s2.0-84921821422en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage10451en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.23.10451
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8012
dc.identifier.volume15en_US
dc.identifier.wosWOS:000351058400069en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAstarcı, Hesna Müzeyyen
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal Of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMelanomaen_US
dc.subjectSkinen_US
dc.subjectPrognostic Factorsen_US
dc.titleA retrospective multicenter evaluation of cutaneous melanomas in Turkeyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
mehmet-gamsizkan.pdf
Boyut:
601.22 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu