Evaluation of preoperative predictors of development of pouchitis after ileal-pouch-anastomosis in ulcerative colitis

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dc.authorid0000-0003-2845-201Xen_US
dc.authorid0000-0003-0664-0976en_US
dc.contributor.authorKalkan, İsmail Hakkı
dc.contributor.authorDağlı, Ülkü
dc.contributor.authorÖnder, Fatih Oğuz
dc.contributor.authorTunç, B.
dc.contributor.authorÖztaş, E.
dc.date.accessioned2021-06-23T19:28:48Z
dc.date.available2021-06-23T19:28:48Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: In this retrospective study, we aimed to evaluate preoperative predictive risk factors for development of pouchitis in the ulcerative colitis (UC) patients with Heal pouch-anal anastomosis (IPAA). Methods: The records of UC patients who underwent IPAA surgery and were under follow-up in the inflammatory bowel disease (IBD) clinic of our hospital between January 1994 and September 2009 were retrieved. Preoperative clinical, biochemical, and endoscopic findings, as well as preoperative endoscopic activity index (EAI), preoperative disease activity index (DAI) and operative characteristics were recorded. Patients with endoscopic, histological and clinical findings consistent with pouchitis were identified. Results: Out of a total of 49 patients who underwent IPAA for UC, pouchitis was identified in 20 (40.8%) of them. Overall, 37 (75.5%) patients had chronic active disease, eight (16.3%) patients had chronic intermittent disease with frequent relapses, and four (8.2%) patients had fulminant colitis prior to surgery. There was a statistically significant difference (P = 0.02) among these patients for the development of pouchitis in postoperative period. The mean EAI (10.1 vs. 8.7, P = 0.02) and DAI (10.0 vs. 8.6, P < 0.01) in patients with pouchitis were significantly higher than that of patients who did not develop pouchitis. Multivariate analysis revealed steroid dependency (P = 0.02), and a higher DAI (P = 0.02) to be independent risk factors for the development of pouchitis. Conclusion: A more severe preoperative clinical course and steroid dependency, as well as higher endoscopic and disease activity scores may be useful as preoperative predictors of subsequent pouchitis in UC patients undergoing IPAA surgery. (c) 2012 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinre.2012.04.012
dc.identifier.endpage627en_US
dc.identifier.issn2210-7401
dc.identifier.issue6en_US
dc.identifier.pmid22705025en_US
dc.identifier.scopus2-s2.0-84870389521en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage622en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinre.2012.04.012
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7070
dc.identifier.volume36en_US
dc.identifier.wosWOS:000314076500019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDağlı, Ülkü
dc.language.isoenen_US
dc.publisherElsevier Massonen_US
dc.relation.ispartofClinics And Research In Hepatology And Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUlcerative Colitisen_US
dc.titleEvaluation of preoperative predictors of development of pouchitis after ileal-pouch-anastomosis in ulcerative colitisen_US
dc.typeArticleen_US

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