Evaluation of pharmaceutical potential and phytochemical analysis of selected traditional lichen species

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dc.authorid0000-0001-7712-2813en_US
dc.authorid0000-0001-9461-2339en_US
dc.authorid0000-0001-9617-6673en_US
dc.contributor.authorTaş, İsa
dc.contributor.authorYıldırım, Arzu Birinci
dc.contributor.authorÖzkan, Erva
dc.contributor.authorÖzyiğitoğlu, Gülşah Çobanoğlu
dc.contributor.authorYavuz, Muhsine Zeynep
dc.contributor.authorTürker, Arzu Uçar
dc.date.accessioned2023-06-20T10:33:20Z
dc.date.available2023-06-20T10:33:20Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Ziraat Fakültesi, Tarla Bitkileri Bölümüen_US
dc.descriptionBolu Abant Izzet Baysal University, Scientific Research Projects (AIBU-BAP)en_US
dc.description.abstractLichens have been commonly used in traditional medicine. Biological potential (anti-proliferative, antioxidant and anti-bacterial) and chemical content of five lichen species (E. divaricata, L. vulpina, L. pulmonaria, R. fraxinea and U. florida) were assessed in relation to traditional knowledge. Consistent with folkloric usage, the strongest anti-proliferative activity was observed with L. pulmonaria against human hepatocellular carcinoma (HepG2/C3A) cell line. L. pulmonaria also showed the highest antioxidant capacity. While E. divaricata had the most phenolic content, the highest flavonoid content was determined in L. pulmonaria. All lichen extracts showed the best antibacterial activity against Gram-positive bacteria and only R. fraxinea had a broad spectrum of antibacterial activity. HPLC-DAD analysis revealed that L. pulmonaria and U. florida were the best sources of stictic acid and usnic acid, respectively. Traditional usages of tested lichens were justified with this study and nutraceutical potentials of them were revealed.en_US
dc.description.abstractStudiul prezintă potențialul biologic (antiproliferativ, antioxidant și antibacterian) și conținutul chimic a cinci specii de licheni (E. divaricata, L. vulpina, L. pulmonaria, R. fraxinea și U. florida) care au fost evaluate în raport cu utilizările tradiționale. Cea mai intensă activitate antiproliferativă a fost observată pentru L. pulmonaria asupra liniei celulare de carcinom hepatocelular uman (HepG2/C3A). L. pulmonaria a prezentat, de asemenea, cea mai pronunțată capacitate antioxidantă. În timp ce E. divaricata a prezentat cel mai mare conținut fenolic, cel mai mare conținut de flavonoide a fost determinat în L. pulmonaria. Toate extractele de lichen au prezentat cea mai bună activitate antibacteriană împotriva bacteriilor Gram-pozitive și doar R. fraxinea a avut un spectru larg de activitate antibacteriană. Analiza HPLC-DAD a arătat că L. pulmonaria și U. florida reprezintă cele mai bune surse de acid stictic și, respectiv, acid usnic. Utilizările tradiționale ale lichenilor testați au fost justificate prin acest studiu și au fost dezvăluite potențialele nutraceutice ale acestora.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University, Scientific Research Projects (AIBU-BAP) [BAP 2014.03.01.702, OBAP 2013.03.01.591]en_US
dc.identifier.citationTas, I., Yildirim, A. B., Ozkan, E., Ozyigitoglu, G. C., Yavuz, M. Z., & Turker, A. U. (2021). Evaluation of pharmaceutical potential and phytochemical analysis of selected traditional lichen species. Farmacia, 69, 1101-1106.en_US
dc.identifier.doi10.31925/farmacia.2021.6.12
dc.identifier.endpage1106en_US
dc.identifier.issn0014-8237
dc.identifier.issn2065-0019
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85122087728en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1101en_US
dc.identifier.urihttp://dx.doi.org/10.31925/farmacia.2021.6.12
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11150
dc.identifier.volume69en_US
dc.identifier.wosWOS:000734305000012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYıldırım, Arzu Birinci
dc.institutionauthorÖzkan, Erva
dc.institutionauthorTürker, Arzu Uçar
dc.language.isoenen_US
dc.publisherSOC STIINTE FARMACEUTICE ROMANIAen_US
dc.relation.ispartofFarmaciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectAnti-proliferativeen_US
dc.subjectHPLCen_US
dc.subjectDıvarıcataen_US
dc.subjectAntioxidant Activityen_US
dc.subjectRamalina Lichensen_US
dc.subjectDivaricataen_US
dc.titleEvaluation of pharmaceutical potential and phytochemical analysis of selected traditional lichen speciesen_US
dc.typeArticleen_US

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