Allergic and autoimmune disorders in families with selective IgA deficiency

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dc.authorid0000-0002-0731-5799
dc.authorid0000-0002-8183-0190
dc.authorid0000-0001-8859-7187
dc.contributor.authorErkoçoğlu, Mustafa
dc.contributor.authorMetin, Ayşe
dc.contributor.authorKaya, Ayşenur
dc.contributor.authorÖzcan, Celal
dc.contributor.authorAkan, Ayşegül
dc.contributor.authorKocabaş, Can Naci
dc.date.accessioned2021-06-23T18:40:28Z
dc.date.available2021-06-23T18:40:28Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/aim: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their first degree relatives (FDRs). Materials and methods: The study included 81 children diagnosed with sIgAD and 274 of their FDRs. The presence of allergic and autoimmune disorders was evaluated and serum antithyroglobulin and antithyroid peroxidase levels were measured in both patients and their first-degree relatives. Results: The mean age of the patients was 9.9 ± 3.9 years. Among the patients with sIgAD, 45.7% of them had at least one allergic disorder and 17.3% of them had at least one autoimmune disorder. The frequencies of asthma, allergic rhinitis, and eczema in the FDRs of sIgAD patients were 10.9%, 9.1%, and 7.7%, respectively. Among their FDRs, 14.6% had autoimmunity, compared to an estimate of 5% in the general population. Conclusion: Increased frequency of allergic and autoimmune disorders in patients with sIgAD and their FDRs suggests a possible common predisposing genetic component for sIgAD and autoimmunity in these families.en_US
dc.identifier.endpage598en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid28425252en_US
dc.identifier.scopus2-s2.0-85018788253en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage592en_US
dc.identifier.trdizinid253757en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpVek56VTNOdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/3118
dc.identifier.volume47en_US
dc.identifier.wosWOS:000399829700033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErkoçoğlu, Mustafa
dc.institutionauthorKocabaş, Can Naci
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAllergyen_US
dc.subjectAutoimmunity
dc.subjectChildren
dc.subjectFirst Degree Relative
dc.subjectSelective IgA Deficiency
dc.subjectAlerji
dc.subjectOtoimmünite
dc.subjectÇocuklar
dc.subjectBirinci Derece Akraba
dc.subjectSelektif IgA Eksikliği
dc.titleAllergic and autoimmune disorders in families with selective IgA deficiencyen_US
dc.typeArticleen_US

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