Can anticarbamylated protein antibodies be used to support the diagnosis of systemic lupus erythematosus?
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Future Medicine Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Autoantibody development plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In this study, we aimed to determine the diagnostic value of anticarbamylated protein antibody (anti-CarP) antibody in SLE and RA patients and its relationship with disease prognosis. Material & method: Fifty-seven SLE patients (F/M 50/7; median age 40.9 +/- 13.7; median disease duration 2 years) who met the 2012 SLICC SLE diagnostic criteria were included in the study. A total of 46 RA patients selected according to the 2010 ACR/EULAR diagnostic criteria (F/M 38/8; median age 54.2 +/- 12.4; median disease duration 2 years) were included. A total of 30 healthy individuals were selected as the control group. The anti-CarP antibody was studied by using human anticarbamylated protein antibody ELISA Kit (SunRedBio, Shanghai, China). Results: Anti-CarP antibody positivity was found to be 17.4% in RA patients (p < 0.001), 54.4% in SLE patients (p < 0.001) and 3.3% in the healthy control group. The anti-CarP antibody was determined to predict SLE patients with 54.4% sensitivity and 96.7% specificity compared with the healthy control group (area under the curve: 0.755; p < 0.001). Conclusion: Anti-CarP antibody positivity was significantly higher in the SLE patients compared with the healthy control and RA group. It has significant sensitivity and specificity in both SLE and RA patients compared with the healthy controls.
Açıklama
Anahtar Kelimeler
Anti-Carp Antibody, Rheumatoid Arthritis, Systemic Lupus Erythematosus
Kaynak
Biomarkers in Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
15
Sayı
14
Künye
Özdemir, B., Erden, A., Erten, Ş., Yeşil, T. H., Alışık, M., & Kucuksahin, O. (2021). Can anticarbamylated protein antibodies be used to support the diagnosis of systemic lupus erythematosus?. Biomarkers in Medicine, 15(14), 1253-1260.
