Dietary vitamin C and E modulates oxidative stress induced-kidney and lens injury in diabetic aged male rats through modulating glucose homeostasis and antioxidant systems

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dc.authorid0000-0003-0887-6974
dc.contributor.authorÖzkaya, Dilek
dc.contributor.authorNazıroğlu, Mustafa
dc.contributor.authorArmağan, Abdullah
dc.contributor.authorDemirel, Alpay
dc.contributor.authorKöroğlu, Banu Kale
dc.contributor.authorKükner, Aysel
dc.date.accessioned2021-06-23T19:28:04Z
dc.date.available2021-06-23T19:28:04Z
dc.date.issued2011
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractDiabetes induces oxidative stress in aged human and rat, although daily supplementation of vitamins C and E (VCE) can be beneficial to aged diabetic rats by reducing free radical production. The aim of the present study was to evaluate whether dietary VCE supplementation relieves oxidative stress in streptozotocin (STZ)-induced diabetic in aged rats. Thirty aged rats were randomly divided into three groups. The first group was used as a control. The second group was made diabetic using a single dose of intraperitoneal STZ. VCE-supplemented feed was given to aged diabetic rats constituting the third group. On the 21st day of the experiment, blood, lens and kidney samples were taken from all animals. Glutathione peroxidase (GSH-Px) activity in lens and kidney, reduced glutathione (GSH), vitamin E and beta-carotene concentrations in kidney were lower in the diabetic group than in the control whereas plasma glucose, urea and creatinine, and kidney and lens peroxidation (LP) levels were higher in the diabetic group than in the control. However, kidney and lens LP levels, and plasma glucose, urea and creatinine values were decreased by VCE supplementation. Lens and kidney GSH-Px activity, kidney GSH, vitamin E and beta-carotene concentrations and erythrocyte counts were increased by VCE treatment. Kidney weights, vitamin A, haemoglobin, hematocrit, leukocyte and platelets values were not changed by diabetes and/or VCE supplementation. VCE ameliorated also diabetes-induced histopathological changes in kidney. In conclusion, we observed that VCE supplementation is beneficial towards kidney and lens of aged diabetic rats by modulating oxidative and antioxidant systems. Copyright (C) 2011 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1749
dc.identifier.endpage293en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue4en_US
dc.identifier.pmid21416480en_US
dc.identifier.scopus2-s2.0-79958863527en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage287en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1749
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6947
dc.identifier.volume29en_US
dc.identifier.wosWOS:000292095300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry And Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetesen_US
dc.subjectAgeden_US
dc.subjectKidneyen_US
dc.subjectLensen_US
dc.subjectVitamin C and Een_US
dc.subjectOxidative Stressen_US
dc.subjectHematological Valuesen_US
dc.titleDietary vitamin C and E modulates oxidative stress induced-kidney and lens injury in diabetic aged male rats through modulating glucose homeostasis and antioxidant systemsen_US
dc.typeArticleen_US

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