N-acetyl cysteine therapy in acute viral hepatitis

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dc.authorid0000-0003-1514-1685en_US
dc.authorid0000-0003-2541-4675
dc.authorid0000-0003-2005-0737
dc.authorid0000-0002-8130-676X
dc.authorid0000-0001-8632-2825
dc.contributor.authorGündüz, Hüseyin
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorTamer, Ali
dc.contributor.authorÖzaras, Reşat
dc.contributor.authorMert, Ali
dc.contributor.authorTabak, Ömer Fehmi
dc.date.accessioned2021-06-23T19:17:30Z
dc.date.available2021-06-23T19:17:30Z
dc.date.issued2003
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAIM: To investigate the effect of N-acetyl cysteine (NAC) on acute viral hepatitis (AVH). METHODS: We administered 200 mg oral NAC three times daily (600 mg/day) to the study group and placebo capsules to the control group. All patients were hospitalized and diagnosed as AVH. Blood total and direct bilirubin, ALT, AST, alkaline phosphatese, albumin and globulin levels of each patient were measured twice weekly until total bilirubin level dropped under 2 mg/dl, ALT level under 100 U/L, follow up was continued and then the patients were discharged. RESULTS: A total of 41(13 female and 28 male) AVH patients were included in our study. The period for normalization of ALT and total bilirubin in the study group was 19.7+/-6.9 days and 13.7+/-8.5 days respectively. In the control group it was 20.4+/-6.5 days and 16.9+/-7.8 days respectively (P>0.05). CONCLUSION: NAC administration effected neither the time necessary for normalization of ALT and total bilirubin values nor duration of hospitalization, so we could not suggest NAC for the treatment of icteric AVH cases. However, our results have shown that this drug is not harmful to patients with AVH.en_US
dc.identifier.endpage2700en_US
dc.identifier.issn1007-9327
dc.identifier.issue12en_US
dc.identifier.pmid14669316en_US
dc.identifier.scopus2-s2.0-0347598079en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2698en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5442
dc.identifier.urihttps://dx.doi.org/10.3748/wjg.v9.i12.2698
dc.identifier.volume9en_US
dc.identifier.wosWOS:000187606800014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGündüz, Hüseyin
dc.institutionauthorKarabay, Oğuz
dc.institutionauthorTamer, Ali
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-acetyl Cysteine Therapyen_US
dc.titleN-acetyl cysteine therapy in acute viral hepatitisen_US
dc.typeArticleen_US

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