Correlation of plasma B-type natriuretic peptide with shunt severity in patients with atrial or ventricular septal defect

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dc.contributor.authorÖzhan, Hakan
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorUzun, Hakan
dc.contributor.authorOrdu, Serkan
dc.contributor.authorKaya, Ahmet
dc.contributor.authorYazıcı, Mehmet
dc.date.accessioned2021-06-23T19:20:01Z
dc.date.available2021-06-23T19:20:01Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe goal of this study was to test the utility of bedside plasma concentration of B-type natriuretic peptide (BNP) assay as a screen for large shunts in pediatric patients with atrial septal defects (ASDs) and ventricular septal defects (VSDs). Thirty-five children at a mean age of 70 +/- 129 weeks with ASD or VSD were included in the study. Nine patients had VSD and 26 had ASD. Plasma BNP values were compared with the Q(p)/Q(s) ratios derived from quantitative Doppler flow measurements. Mean BNP was 29 +/- 42 pg/ml, with a range between < 5 pg/ml and 208 pg/ml. Sixteen patients had Q(p)/Q(s) values > 1.5 and 19 had values < 1.5. The difference of mean BNP in these patient groups was statistically significant (45 +/- 56 vs 14 +/- 17, p = 0.03). BNP was positively correlated with shunt significance. Receiver operating characteristic curve analysis revealed a sensitivity of 69% and a specificity of 79% at a plasma BNP cut-off level of >= 20 pg/ml. Bedside measurement of BNP correlates with magnitude of ASD and VSD in children. BNP can provide information for the management of children with ASD or VSD. It can be used as part of the evaluation of a child with a preliminary diagnosis of a congenital defect.en_US
dc.identifier.doi10.1007/s00246-006-0014-3
dc.identifier.endpage275en_US
dc.identifier.issn0172-0643
dc.identifier.issn1432-1971
dc.identifier.issue4en_US
dc.identifier.pmid17530321en_US
dc.identifier.scopus2-s2.0-34250862152en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage272en_US
dc.identifier.urihttps://doi.org/10.1007/s00246-006-0014-3
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6045
dc.identifier.volume28en_US
dc.identifier.wosWOS:000247464700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzhan, Hakan
dc.institutionauthorAlbayrak, Sinan
dc.institutionauthorYazıcı, Mehmet
dc.institutionauthorOrdu, Serkan
dc.institutionauthorUzun, Hakan
dc.institutionauthorKaya, Ahmet
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectB-type Natriuretic Peptideen_US
dc.subjectAtrial Septal Defecten_US
dc.subjectVentricular Septal Defecten_US
dc.titleCorrelation of plasma B-type natriuretic peptide with shunt severity in patients with atrial or ventricular septal defecten_US
dc.typeArticleen_US

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