Does c-reactive protein to serum albumin ratio correlate with diabetic nephropathy in patients with type 2 diabetes mellitus? The care time study

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dc.authorid0000-0002-4162-5563en_US
dc.authorid0000-0002-3836-2125en_US
dc.authorid0000-0001-7306-5233en_US
dc.contributor.authorBilgin, Satılmış
dc.contributor.authorKurtkulağı, Özge
dc.contributor.authorTel, Burcin Meryem Atak
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorKahveci, Gizem
dc.contributor.authorKhalid, Atiqa
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2023-07-24T12:40:54Z
dc.date.available2023-07-24T12:40:54Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAims: Diabetic Nephropathy (DN) is a complication of Diabetes Mellitus and is associated with chronic and low-grade inflammatory burden. Novel inflammatory predictors, such as, C-reactive protein to serum albumin ratio (CAR) has been studied various inflammatory conditions, recently. Increased inflammatory burden accompany to both type 2 Diabetes Mellitus (T2DM) and DN, hence we aimed to compare CAR levels of the T2DM subjects with DN to those of without DN. Methods: Patients with T2DM were enrolled to the study. Study population grouped into two according to the presence (group A) or absence (group B) of DN. Characteristics and laboratory data, as well as CAR levels; of the study groups were compared. Results: Median CAR levels of the groups A and B were 2.17% (0.02-13.2) and 0.39% (0.02-4.39), respectively (p < 0.001). CAR was found to be an independent risk factor for diabetic nephropathy (adjusted to age, BMI, fasting glucose, HbA1c, and body weight). One unit (0.1%) elevation in CAR increased the risk of nephropathy by 3.5 folds (p < 0.001, 95%CI: 2.24-5.45). CAR levels greater than 0.82% have 79% sensitivity and 78% specificity in predicting DN (AUC: 0.86 [95% CI: 0.80-0.92]; p < 0.001). Conclusions: In conclusion, elevated CAR levels are higher in type 2 diabetic patients with diabetic nephropathy. According to the ROC curve, a level higher than 0.82% presents the best sensitivity and specificity in the association with the presence of DN. (c) 2021 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationBilgin, S., Kurtkulagi, O., Tel, B. M. A., Duman, T. T., Kahveci, G., Khalid, A., & Aktas, G. (2021). Does C-reactive protein to serum Albumin Ratio correlate with diabEtic nephropathy in patients with Type 2 dIabetes MEllitus? The CARE TIME study. Primary care diabetes, 15(6), 1071-1074.en_US
dc.identifier.doi10.1016/j.pcd.2021.08.015
dc.identifier.endpage1074en_US
dc.identifier.issn1751-9918
dc.identifier.issn1878-0210
dc.identifier.issue6en_US
dc.identifier.pmid34497035en_US
dc.identifier.scopus2-s2.0-85114433441en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1071en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.pcd.2021.08.015
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11346
dc.identifier.volume15en_US
dc.identifier.wosWOS:000744235900022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKurtkulağı, Özge
dc.institutionauthorTel, Burçin Meryem Atak
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofPrimary Care Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectInflammationen_US
dc.subjectC-Reactive Protein To Albumin Ratioen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectProtein/Albumin Ratioen_US
dc.subjectFibrosisen_US
dc.titleDoes c-reactive protein to serum albumin ratio correlate with diabetic nephropathy in patients with type 2 diabetes mellitus? The care time studyen_US
dc.typeArticleen_US

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