Prospective analysis of febrile neutropenia patients with bacteraemia: The results of an international ID-IRI study

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dc.authorid0000-0003-0442-5981en_US
dc.authorid0000-0002-3613-0523en_US
dc.contributor.authorSırmatel, Fatma
dc.contributor.authorKocoğlu, Esra
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorEl-Sokkary, Rehab
dc.contributor.authorHakamifard, Atousa
dc.contributor.authorErdem, Hakan
dc.date.accessioned2024-05-06T13:09:07Z
dc.date.available2024-05-06T13:09:07Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: Bacteraemia during the course of neutropenia is often fatal. We aimed to identify factors predicting mortality to have an insight into better clinical management.Methods: The study has a prospective, observational design using pooled data from febrile neutropenia patients with bacteraemia in 41 centres in 16 countries. Polymicrobial bacteraemias were excluded. It was performed through the Infectious Diseases-International Research Initiative platform between 17 March 2021 and June 2021. Univariate analysis followed by a multivariate binary logistic regression model was used to determine independent predictors of 30-d in-hospital mortality (sensitivity, 81.2%; specificity, 65%). Results: A total of 431 patients were enrolled, and 85 (19.7%) died. Haematological malignancies were detected in 361 (83.7%) patients. Escherichia coli (n = 117, 27.1%), Klebsiellae (n = 95, 22% %), Pseudomonadaceae (n = 63, 14.6%), Coagulase-negative Staphylococci (n = 57, 13.2%), Staphylococcus aureus (n = 30, 7%), and Enterococci (n = 21, 4.9%) were the common pathogens. Meropenem and piperacillin-tazobactam susceptibility, among the isolated pathogens, were only 66.1% and 53.6%, respectively. Pulse rate (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002-1.034), quick SOFA score (OR, 2.857; 95% CI, 2.120- 3.851), inappropriate antimicrobial treatment (OR, 1.774; 95% CI, 1.011-3.851), Gram-negative bacteraemia (OR, 2.894; 95% CI, 1.437-5.825), bacteraemia of non-urinary origin (OR, 11.262; 95% CI, 1.368-92.720), and advancing age (OR, 1.017; 95% CI, 1.001-1.034) were independent predictors of mortality. Bacteraemia in our neutropenic patient population had distinctive characteristics. The severity of infection and the way to control it with appropriate antimicrobials, and local epidemiological data, came forward. Conclusions: Local antibiotic susceptibility profiles should be integrated into therapeutic recommendations, and infection control and prevention measures should be prioritised in this era of rapidly increasing antibiotic resistance.& COPY; 2023 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.en_US
dc.identifier.citationErdem, H., Kocoglu, E., Ankarali, H., El-Sokkary, R., Hakamifard, A., Karaali, R., ... & Sirmatel, F. (2023). Prospective analysis of febrile neutropenia patients with bacteraemia: the results of an international ID–IRI study. International journal of antimicrobial agents, 62(3), 106919.en_US
dc.identifier.doi10.1016/j.ijantimicag.2023.106919
dc.identifier.endpage10en_US
dc.identifier.govdocPUBMED ID: 37423582
dc.identifier.issn0924-8579
dc.identifier.issn1872-7913
dc.identifier.issue3en_US
dc.identifier.pmid37423582en_US
dc.identifier.scopus2-s2.0-85168807565en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijantimicag.2023.106919
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12120
dc.identifier.volume62en_US
dc.identifier.wosWOS:001063127400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSırmatel, Fatma
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Antimicrobial Agentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFebrile Neutropeniaen_US
dc.subjectBacteraemiaen_US
dc.subjectAntimicrobialen_US
dc.subjectResistanceen_US
dc.subjectAntibiotic Stewardshipen_US
dc.subjectBlood Culturesen_US
dc.titleProspective analysis of febrile neutropenia patients with bacteraemia: The results of an international ID-IRI studyen_US
dc.typeArticleen_US

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