Rewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linalool

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dc.authorid0000-0003-1075-9574en_US
dc.contributor.authorYunusoğlu, Oruç
dc.date.accessioned2023-11-17T06:18:44Z
dc.date.available2023-11-17T06:18:44Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionThis study was financially supported in part by the Van Yuzuncu Yil University (Research Funding No: THD-2020-8964).en_US
dc.description.abstractAlcohol addiction is a chronic relapsing disease that is progressive and has severe detrimental health outcomes. The use of natural products has become popular for the treatment of side effects of drugs and substance abuse. Linalool is a monoterpenoid that exhibits several effects on the central nervous system. Linalool was identified to have beneficial effects on different mechanisms that are relevant in drug addiction or substance use disorder. The primary aim of the present study was to evaluate the therapeutic effect of linalool on the rewarding properties of alcohol in mice. Conditioned place preference (CPP) was established by intraperitoneal (i.p.) injection of ethanol (2 g/kg) during an 8-day conditioning trial. The effects of acamprosate and linalool on the rewarding properties of ethanol were tested in mice who received linalool (12.5, 25, and 50 mg/kg, i.p.) and acamprosate (300 mg/kg, i.p.) 30 min before each ethanol injection. CPP was extinguished by repeated testing, throughout which conditioned mice were administered daily linalool. Mice were lastly examined for reinstatement provoked by i.p. administration of single low-dose ethanol (0.4 g/kg, i.p.). Treatment with linalool reduced the acquisition and reinstatement, and precipitated the extinction of ethanol-induced CPP in mice. Acquisition and reinstatement of alcohol-induced CPP were significantly reduced by acamprosate, which also precipitated extinction. Ethanol alone and the combination with linalool or acamprosate did not alter locomotor activity. The results of this study suggest that linalool may have pharmacological effects for the treatment of alcohol addiction. In addition, further investigation is required to fully explore the benefits and possible adverse effects of linalool on alcohol addiction. (C) 2021 Elsevier Inc.en_US
dc.description.sponsorshipVan Yuzuncu Yil University [THD-2020-8964]en_US
dc.identifier.citationYunusoğlu, O. (2022). Rewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linalool. Alcohol, 98, 55-63.en_US
dc.identifier.doi10.1016/j.alcohol.2021.11.003
dc.identifier.endpage63en_US
dc.identifier.issn0741-8329
dc.identifier.issn1873-6823
dc.identifier.pmid34800613en_US
dc.identifier.scopus2-s2.0-85120984394en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage55en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.alcohol.2021.11.003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11850
dc.identifier.volume98en_US
dc.identifier.wosWOS:000798515600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYunusoğlu, Oruç
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAlcoholen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlcoholen_US
dc.subjectConditioned Place Preferenceen_US
dc.subjectLinaloolen_US
dc.subjectProliferator-Activated Receptorsen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectNMDA Receptoren_US
dc.titleRewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linaloolen_US
dc.typeArticleen_US

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