Interleukin-10 gene promoter polymorphism in patients with schizophrenia in a region of East Turkey

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dc.authorid0000-0002-2408-5294en_US
dc.authorid0000-0002-6023-818X
dc.contributor.authorÖzbey, Ülkü
dc.contributor.authorTuğ, Esra
dc.contributor.authorNamlı, Mustafa
dc.date.accessioned2021-06-23T19:26:01Z
dc.date.available2021-06-23T19:26:01Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractSchizophrenia is one of the most severe psychiatric disorders, with a worldwide incidence of 1%. Immunological abnormalities have been found to be associated with schizophrenia for decades. Cytokines are key proteins involved in the immune system activation. Interleukin-10 (IL-10), an important immunoregulatory cytokine, is located on chromosome 1q31 32, a region previously reported to be linked to schizophrenia in genetic studies. In the present study it was aimed to examine the IL-10 gene promoter region's polymorphic variants in patients with schizophrenia in a population of the Elazig Region of East Anatolia, Turkey. Polymorphisms at position -1082, -819 and -592 in the IL-10 promoter region were determined in 171 Turkish patients who were diagnosed with schizophrenia, based on the DSM-IV, and 168 healthy controls, by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). We analyzed allele, genotype, and haplotype distributions using a case-control association study. Genotyping was performed by RFLP. Statistically significant differences were observed in both allelic and genotypic frequencies of the -592A/C polymorphism (Allele, P = 0.034, OR = 1.26, 95% CI 1.02 - 1.56; Genotype, P = 0.048), while the other two polymorphisms in distribution of the alleles and genotypes in patients with schizophrenia were not significantly different from those of controls (P > 0.05). Our results show a significant increase of GTA homozygotes (the high IL-10-producing haplotype) in schizophrenic patients compared to control subjects (P = 0.0001). These data suggest that the IL-10 gene promoter polymorphism may be one of the susceptibility factors to develop schizophrenia in the Turkish population, and apparently in all humans.en_US
dc.identifier.doi10.1080/15622970802626580
dc.identifier.endpage468en_US
dc.identifier.issn1562-2975
dc.identifier.issn1814-1412
dc.identifier.issue4en_US
dc.identifier.pmid19153889en_US
dc.identifier.scopus2-s2.0-77449129201en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage461en_US
dc.identifier.urihttps://doi.org/10.1080/15622970802626580
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6378
dc.identifier.volume10en_US
dc.identifier.wosWOS:000273003200015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTuğ, Esra
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltd.en_US
dc.relation.ispartofWorld Journal Of Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological Psychiatryen_US
dc.subjectCytokinesen_US
dc.subjectGeneticsen_US
dc.subjectPolymorphismen_US
dc.subjectSchizophreniaen_US
dc.titleInterleukin-10 gene promoter polymorphism in patients with schizophrenia in a region of East Turkeyen_US
dc.typeArticleen_US

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