Effects of lexipafant (BB-882), a platelet activating factor receptor antagonist, on liver damage due to bile duct ligation in rats

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dc.authorid0000-0003-1719-4924
dc.authorid0000-0001-5608-5742
dc.authorid0000-0002-1162-5140
dc.authorid0000-0001-9396-9803
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorDokucu, Ali İhsan
dc.contributor.authorOtçu, Selçuk
dc.date.accessioned2021-06-23T19:19:14Z
dc.date.available2021-06-23T19:19:14Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and study aims : Extrahepatic cholestasis is one of the main factors causing liver fibrosis. In this study, we aimed to evaluate the effects of lexipafant (BB-882), a platelet activating factor receptor antagonist, on liver damage in rats with bile duct ligation. Methods: A total of 30 male Sprague-Dawley rats weighing 160-190 g were used in this study. Group I (Sham-control, n = 10) rats were undergone laparotomy alone and bile duct was just dissected from the surrounding tissue. Group 2 rats (BDL/Untreated, n = 10) were subjected to bile duct ligation and no drug was applied. Group 3 rats (BDUBB-882, n = 10) received a daily dose of BB-882 intraperitoneally for 14 days after BDL. At the end of the two-week period, biochemical and histological evaluation was processed. Results : The mean serum bilirubin and liver enzymes level significantly decreased, and Superoxide dismutase, catalase and glutathione peroxidase values were significantly increased in BDL/BB-882 group when compared to BDUUntreated group. The histopathological score was significantly less in the BDUBB-882 group compared to the BDL/Untreated rats. In the BDL/BB-882 group was observed less fibrosis and neutrophil infiltration. Conclusions : These results suggest that BB-882 (lexipafant) may reduce the severity of the inflammatory response to liver injury produced by bile duct ligation in rats.en_US
dc.identifier.endpage202en_US
dc.identifier.issn1784-3227
dc.identifier.issue2en_US
dc.identifier.pmid16929615en_US
dc.identifier.scopus2-s2.0-33747621139en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5902
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33747621139&partnerID=40&md5=6332cc1fee1ca20417817af1fa1a7542
dc.identifier.volume69en_US
dc.identifier.wosWOS:000240612900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Hayrettin
dc.language.isoenen_US
dc.publisherUniv Catholique Louvain-Uclen_US
dc.relation.ispartofActa Gastro-Enterologica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBile Duct Ligationen_US
dc.subjectBB-882en_US
dc.subjectLexipafanten_US
dc.subjectRaten_US
dc.titleEffects of lexipafant (BB-882), a platelet activating factor receptor antagonist, on liver damage due to bile duct ligation in ratsen_US
dc.typeArticleen_US

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