Bactericidal permeability increasing protein gene polymorphism is associated with inflammatory bowel diseases in the Turkish population

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dc.authorid0000-0001-9449-175Xen_US
dc.authorid0000-0001-6144-5220en_US
dc.authorid0000-0002-6054-9244en_US
dc.contributor.authorCan, Güray
dc.contributor.authorAkın, Hakan
dc.contributor.authorÖzdemir, Filiz Türe
dc.contributor.authorCan, Hatice
dc.contributor.authorYılmaz, Bülent
dc.date.accessioned2021-06-23T19:42:00Z
dc.date.available2021-06-23T19:42:00Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/Aims: Inflammatory bowel disease, a chronic inflammatory disease with unknown etiology, affects the small and large bowel at different levels. It is increasingly considered that innate immune system may have a central position in the pathogenesis of the disease. As a part of the innate immune system, bactericidal permeability increasing protein has an important role in the recognition and neutralization of gram-negative bacteria. The aim of our study was to investigate the involvement of bactericidal permeability increasing protein gene polymorphism (bactericidal permeability increasing protein Lys216Glu) in inflammatory bowel disease in a large group of Turkish patients. Patients and Methods: The present study included 528 inflammatory bowel disease patients, 224 with Crohn's disease and 304 with ulcerative colitis, and 339 healthy controls. Results: Bactericidal permeability increasing protein Lys216Glu polymorphism was found to be associated with both Crohn's disease and ulcerative colitis (P = 0.0001). The frequency of the Glu/Glu genotype was significantly lower in patients using steroids and in those with steroid dependence (P = 0.012, OR, 0.80; 95% confidence interval [CI]: 0.68-0.94; P = 0.0286, OR, 0.75; 95% CI: 0.66-0.86, respectively). There was no other association between bactericidal permeability increasing protein gene polymorphism and phenotypes of inflammatory bowel disease. Conclusions: Bactericidal permeability increasing protein Lys216Glu polymorphism is associated with both Crohn's disease and ulcerative colitis. This is the first study reporting the association of bactericidal permeability increasing protein gene polymorphism with steroid use and dependence in Crohn's disease.en_US
dc.identifier.doi10.4103/1319-3767.161642
dc.identifier.endpage244en_US
dc.identifier.issn1319-3767
dc.identifier.issn1998-4049
dc.identifier.issue4en_US
dc.identifier.pmid26228368en_US
dc.identifier.scopus2-s2.0-84938389348en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://doi.org/10.4103/1319-3767.161642
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8288
dc.identifier.volume21en_US
dc.identifier.wosWOS:000358778800010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCan, Güray
dc.institutionauthorCan, Hatice
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofSaudi Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBactericidal Permeability Increasing Proteinen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.titleBactericidal permeability increasing protein gene polymorphism is associated with inflammatory bowel diseases in the Turkish populationen_US
dc.typeArticleen_US

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