Continuous infusion of small-volume fluid resuscitation in the treatment of combined uncontrolled hemorrhagic shock and Head Injury

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dc.authorid0000-0002-0437-7206en_US
dc.authorid0000-0001-5608-5742
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorYağmur, Yusuf
dc.contributor.authorTaş, Aşkın
dc.contributor.authorTopçu, Soykan
dc.contributor.authorOrak, Murat
dc.date.accessioned2021-06-23T19:20:43Z
dc.date.available2021-06-23T19:20:43Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To determine-the effect of continuous limited fluid resuscitation on the hemodynamic response and survival in rats in a model of uncontrolled hemorrhage shock due to Massive Splenic Injury (MSI) and Head Injury (HI). Design: An experimental study. Place and Duration of Study: Dicle University Animal Research Laboratory, Turkey, between January and February 2005. Subjects and Methods: Seventy Sprague-Dawley rats were used in this study. Group 1 rats (n=10) was sham-operated. In group 2 (n=10), only Massive Splenic Injury (MSI) was performed and untreated. In group 3 (n=10), only head injury (HI) was performed and untreated. In group 4 (n=10), HI and MSI were performed and were untreated. In group 5 (n=10), HI and MSI were performed and 15 minutes later treated with 7.5% NaCl. In group 6 (n=10), HI and MSI were performed, and rats were treated with Ringer's Lactate (RL) solution. In group 7 (n=10), HI and MSI were performed, rats were treated with 0.9% NaCl. In groups 2,4,5,6 and 7 midline incision was reopened and splenectomy was performed at 45 minutes. Results: In group 4 rats, Mean Arterial Pressure (MAP) was decreased from 104 +/- 6.1 mmHg to 75 +/- 19.5 mmHg at 15 minutes; heart rate decreased from 357 +/- 24.9 beats/min to 321 +/- 62.1 beats/min and hematocrit decreased from 46 +/- 1.3% to 43 +/- 2.5% (p<0.01). Similar early changes in MAP, heart rate and hematocrit were observed in groups 5, 6, and 7, at 15 minutes. At 45,60 and 120 minutes, in fluid resuscitated rats (group 5,6,7) MAP, heart rate and hematocrit values were measured higher than group 2 and 4 (p<0.01 for all). At 120 min. in group 6, hematocrit was higher than group 4, 5 and 7, in group 6, total blood loss after splenectomy was calculated at 20 +/- 2.4% of blood volume and was the best value compared to other fluid resuscitated group 5 and 7 (28% and 27% of blood volume) (p<0.01). Mortality was lower in all fluid resuscitated groups when compared to group 3 and 4 (p<0.05). The median survival time was again higher in fluid resuscitated groups. Conclusion: Continuous infusion of 7.5% NaCl, RL and 0.9% NaCl following uncontrolled hemorrhagic shock with massive splenic injury and combined head injury resulted in better survival and RL did not increase abdominal bleeding before splenectomy was performed.en_US
dc.identifier.endpage22en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue1en_US
dc.identifier.pmid17204214en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6157
dc.identifier.urihttps://jcpsp.pk/archive/2007/Jan2007/article5.pdf
dc.identifier.volume17en_US
dc.identifier.wosWOS:000257138200006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Hayrettin
dc.institutionauthorYağmur, Yusuf
dc.language.isoenen_US
dc.publisherCollege Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJcpsp-Journal Of The College Of Physicians And Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUncontrolled hemorrhagic shocken_US
dc.subjectHead injuryen_US
dc.subjectRaten_US
dc.subjectFluid resuscitationen_US
dc.titleContinuous infusion of small-volume fluid resuscitation in the treatment of combined uncontrolled hemorrhagic shock and Head Injuryen_US
dc.typeArticleen_US

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