The effects of Gum Arabic, curcumin (Curcuma longa) and Garcinia kola on the rat hippocampus after electromagnetic field exposure: A stereological and histological study

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dc.authorid0000-0001-9254-175Xen_US
dc.authorid0000-0003-1477-5002en_US
dc.authorid0000-0003-1424-501Xen_US
dc.contributor.authorElamin, Abdalla Ahmed Eldaw
dc.contributor.authorDeniz, Ömür Gülsüm
dc.contributor.authorKaplan, Süleyman
dc.date.accessioned2023-05-30T13:01:22Z
dc.date.available2023-05-30T13:01:22Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe present study was designed to focus on the potential effects of the electromagnetic field (EMF) emitted by mobile phones on hippocampal pyramidal neurons and to investigate the role of curcumin (Cur), Garcinia kola (GK) and Gum Arabic (GA) in reducing these adverse effects. Fifty-four 12-week-old male Wistar albino rats were used. These were randomly divided into nine groups of six rats each. The control, Cur, GK and GA groups were not exposed to EMF, while the sham group was kept in the EMF exposure system without being exposed to EMF. The EMF+Cur, EMF+GK, EMF+GA and EMF groups were exposed to 900 MHz EMF for one hour a day for 28 days. The number of the pyramidal neurons in the cornu ammonis (CA) of the hippocampus was estimated using the optical fractionator technique. Histopathological changes were evaluated under light and electron microscopes. The activities of the superoxide dismutase (SOD) and catalase (CAT) enzymes were also evaluated from serum samples. Significant levels of CAT and SOD activities were observed in the EMF group compared to the control group (p = 0.000; p = 0.001) respectively. Microscopic observations showed that dark-coloured nuclei with unclear neuron boundaries were frequently observed in the EMF group. Stereological data analysis revealed a significant decrease in the CA's total number of pyramidal neurons in the EMF group compared to the control and sham groups (p = 0.000; p = 0.000) respectively. Cur and GK were observed to provide significant protection in the EMF+Cur and EMF+GK groups compared to the EMF group (p = 0.000; p = 0.000) respectively. No significant difference was observed between the EMF+GA group and EMF group (p = 0.989). Exposure to 900 MHz EMF causes severe alterations in the number and structure of hippocampal pyramidal neurons. Cur and GK exhibit a protective effect against these deleterious effects, but GA showed no protective effect.en_US
dc.identifier.citationElamin, A. A. E., Deniz, O. G., & Kaplan, S. (2022). The effects of Gum Arabic, curcumin (Curcuma longa) and Garcinia kola on the rat hippocampus after electromagnetic field exposure: A stereological and histological study. Journal of Chemical Neuroanatomy, 120, 102060.en_US
dc.identifier.doi10.1016/j.jchemneu.2021.102060
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.pmid34915150en_US
dc.identifier.scopus2-s2.0-85121347545en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.jchemneu.2021.102060
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11006
dc.identifier.volume120en_US
dc.identifier.wosWOS:000752784200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDeniz, Ömür Gülsüm
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofJournal of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectromagnetic Fielden_US
dc.subjectHippocampusen_US
dc.subjectStereologyen_US
dc.subjectMobile Phone Radiationen_US
dc.subjectPyramidal Cell Lossen_US
dc.subjectPrenatal Exposureen_US
dc.titleThe effects of Gum Arabic, curcumin (Curcuma longa) and Garcinia kola on the rat hippocampus after electromagnetic field exposure: A stereological and histological studyen_US
dc.typeArticleen_US

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