Effects of high dose retinoic acid on TGF-beta 2 expression during pancreatic organogenesis

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dc.authorid0000-0003-1364-4684
dc.authorid0000-0001-5387-2628
dc.authorid0000-0002-1197-2468
dc.authorid0000-0003-3310-8803
dc.contributor.authorÇolakoğlu, Neriman
dc.contributor.authorKükner, Aysel
dc.contributor.authorÖner, Jale
dc.contributor.authorSönmez, M. Fatih
dc.contributor.authorÖner, Hakan
dc.contributor.authorOzan, Enver
dc.date.accessioned2021-06-23T19:18:15Z
dc.date.available2021-06-23T19:18:15Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to investigate the effects of excess all-trans retinoic acid, a vitamin A metabolite, on pancreatic organogenesis and TGF-beta 2 expression during prenatal development in rats. First group of animals used as control while a single dose of 60 mg/kg all-trans retinoic acid was ingested by the mothers, at day 8 of gestation (before the neurulation period) in group II and at day 12 of gestation (after the neurulation period) in group III, and all embryos were sacrificed at day 18 of gestation. TGF-beta 2 expression was detected in the capsule, acini and Langerhans islets in the control group. In the pancreas of group II, dilatation and congestion of interlobular vessels were observed. Langerhans islet structures were completely absent. Moreover acinar TGF-beta 2 immune reactivity was not determined. In group III, acinar expression of TGF-beta 2 in acid was similar to that in the controls but their Langerhans islets TGF-beta 2 immune reactivity was significantly less than the controls. In view of the present findings we suggest that TGF-beta 2 plays important role in pancreatic morphogenesis and administration of excess all-trans retinoic acid before neurulation inhibit TGF-beta 2 expression disrupted pancreatic morphogenesis particularly Langerhans islets. However, its administration after neurulation had less adverse affect on pancreatic organogenesis and TGF-beta 2 immune reactivity.en_US
dc.identifier.doi10.1007/s10735-005-9013-6
dc.identifier.endpage418en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue6-7en_US
dc.identifier.pmid16479313en_US
dc.identifier.scopus2-s2.0-33646878085en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage413en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-005-9013-6
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5680
dc.identifier.volume36en_US
dc.identifier.wosWOS:000237671700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPancreasen_US
dc.subjectPrenatal Developmenten_US
dc.subjectTGF-beta 2en_US
dc.subjectImmunohistochemistryen_US
dc.titleEffects of high dose retinoic acid on TGF-beta 2 expression during pancreatic organogenesisen_US
dc.typeArticleen_US

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