Serum omentin-1 levels in diabetic and nondiabetic patients with chronic kidney disease

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dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0002-3156-1076en_US
dc.authorid0000-0002-4542-4064
dc.authorid0000-0002-5924-7476
dc.contributor.authorTekçe, Hikmet
dc.contributor.authorTekçe, Buket Kın
dc.contributor.authorAktaş, Gülali
dc.contributor.authorAlçelik, Aytekin
dc.contributor.authorŞengül, Erkan
dc.date.accessioned2021-06-23T19:37:09Z
dc.date.available2021-06-23T19:37:09Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Omentin-1, a novel adipokine identified in visceral adipose tissue, is negatively correlated with different conditions such as diabetes, obesity and inflammation. However, changes in serum Omentin levels associated with the degree of the renal dysfunction and metabolic risk factors in CKD patients has not yet been revealed. In the present study, we aimed to investigate the level of Omentin-1 and related para meters in diabetic and non-diabetic CKD patients. Methods: 64 (30 diabetic, 34 non-diabetic) CKD patients and 27 healthy control subjects enrolled in this cross-sectional study. Anthropometric and laboratory assessment performed and malnutrition and inflammation components evaluated. Serum concentrations of Omentin-1 and insulin were measured by using ELISA. Results: Serum Omentin-1 levels in CKD patients were significantly lower compared to the healthy controls. Further analyze revealed that decreased omentin in CKD patients was due to the reduced omentin levels in the diabetic subgroup. An increase in inflammation and malnutrition components was correlated with a decrease in the serum level of Omentin. Omentin levels were lower in stage 2 and 3 CKD but not stage 4 CKD patients compared to control. Conclusions: The results of the present study suggest that diabetes mellitus and inflammation should be associated with lower omentin levels in CKD population; however, this reduction resolves due to the failure of degradation and excretion of omentin when creatinine clearance falls below 30 ml/min (stage 4 CKD).en_US
dc.identifier.doi10.1055/s-0034-1375674
dc.identifier.endpage456en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue8en_US
dc.identifier.pmid24918534en_US
dc.identifier.startpage451en_US
dc.identifier.urihttps://doi.org/10.1055/s-0034-1375674
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8114
dc.identifier.volume122en_US
dc.identifier.wosWOS:000346270300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTekçe, Hikmet
dc.institutionauthorTekçe, Buket Kın
dc.institutionauthorAktaş, Gülali
dc.institutionauthorAlçelik, Aytekin
dc.language.isoenen_US
dc.publisherJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbhen_US
dc.relation.ispartofExperimental And Clinical Endocrinology & Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOmentinen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectInflammationen_US
dc.titleSerum omentin-1 levels in diabetic and nondiabetic patients with chronic kidney diseaseen_US
dc.typeArticleen_US

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