Is serum uric acid-to-HDL cholesterol ratio elevation associated with diabetic kidney injury?

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dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0002-5013-4600en_US
dc.authorid0000-0002-3836-2125en_US
dc.authorid0000-0003-2811-0052en_US
dc.authorid0000-0003-3651-4858en_US
dc.authorid0000-0003-4201-9757en_US
dc.contributor.authorAktaş, Gülali
dc.contributor.authorYılmaz, Şeyma
dc.contributor.authorKantarcı, Didar Beyza
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorBilgin, Satılmış
dc.contributor.authorBalcı, Sümeyye Buse
dc.contributor.authorTel, Burçin Meryem Atak
dc.date.accessioned2024-03-11T06:49:51Z
dc.date.available2024-03-11T06:49:51Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectivesDiabetic kidney injury (DKI) is a serious microvascular complicationof type 2 diabetes mellitus (T2DM). Novel markers are being developedto make a timely diagnosis of this complication. Uric Acid to HDLratio (UHR) was reported to be associated with inflammatory andmetabolic diseases such as metabolic syndrome, type 2 diabetesmellitus, thyroiditis, and nonalcoholic hepatosteatosis, recently. Inthe present study, we aimed to show the diagnostic role of UHR indiabetic kidney injury (DKI), a condition characterized with chronicand low-grade inflammation.MethodsWe retrospectively analyzed data of 287 patients who already had T2D Min outpatient clinics of our institution. The study population was divided into two groups according to the presence of DKI. General characteristics and laboratory data, including UHR levels, of the diabetic subjects with DKI were compared to those of patients without DKI.ResultsThe median UHR of the diabetic patients with DKI group (0,13 (0,06-0,33)) was significantly elevated compared to the UHR of diabetic patients without DKI (0,11 (0,04-0,34)) (p < 0.001). Median UHR was significantly and positively correlated with UACR (r=0.14, p=0.02), serum creatinine (r=0.18, p=0.002), and HbA1c (r=0.28, p<0.001) levels. There was also a significant inverse correlation between UHR and GFR (r=-0.19, p=0.001) values. Logistic regression analysis confirmed that a 0.1 point increase in UHR increases DKI odds by 2.3 times. UHR was also correlated with serum creatinine, GFR, and UACR, which are important signs for DKI.ConclusionIn conclusion, we think that UHR could be a diagnostic tool indiabetic kidney injury according to the preliminary results of the present study. UHR has an independent predictive role in DKI, and ithas significant correlation with other markers of kidney functions, therefore, we suggest routine evaluation of UHR in patients with DKIalong with other markers such as serum creatinine, GFR, and UACR.en_US
dc.identifier.citationAktas, G., Yilmaz, S., Kantarci, D. B., Duman, T. T., Bilgin, S., Balci, S. B., & Atak Tel, B. M. (2023). Is serum uric acid-to-HDL cholesterol ratio elevation associated with diabetic kidney injury?. Postgraduate medicine, 135(5), 519-523.en_US
dc.identifier.doi10.1080/00325481.2023.2214058
dc.identifier.endpage523en_US
dc.identifier.issn0032-5481
dc.identifier.issn1941-9260
dc.identifier.issue5en_US
dc.identifier.pmid37170820en_US
dc.identifier.scopus2-s2.0-85159463056en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage519en_US
dc.identifier.urihttp://dx.doi.org/10.1080/00325481.2023.2214058
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12072
dc.identifier.volume135en_US
dc.identifier.wosWOS:000987532800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAktaş, Gülali
dc.institutionauthorYılmaz, Şeyma
dc.institutionauthorKantarcı, Didar Beyza
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorBilgin, Satılmış
dc.institutionauthorBalcı, Sümeyye Buse
dc.institutionauthorTel, Burçin Meryem Atak
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPostgraduate Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectDiabetic Kidney Injuryen_US
dc.subjectUric Acid-To-HDL Cholesterol Ratioen_US
dc.subjectInflammationen_US
dc.subjectComplicationen_US
dc.subjectNephropathyen_US
dc.titleIs serum uric acid-to-HDL cholesterol ratio elevation associated with diabetic kidney injury?en_US
dc.typeArticleen_US

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