Effect of age on the response to in vitro ischemia and reperfusion of the rabbit bladder

Basit Öğe Kaydı
dc.contributor.authorAğartan, Canan Aldırmaz
dc.contributor.authorLeggett, Robert E.
dc.contributor.authorKogan, Barry A.
dc.contributor.authorLevin, Robert M.
dc.date.accessioned2021-06-23T19:20:51Z
dc.date.available2021-06-23T19:20:51Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/ Aims: Urinary bladder dysfunction secondary to outlet obstruction is a common condition, seen in both children and adults. Using in vitro models of ischemia/ reperfusion ( I/ R), we compared the contractile and biochemical responses of bladders isolated from young and old rabbits. Materials and Methods: Fourteen male New Zealand White rabbits were separated into two groups of 7. Group 1 ( young) included rabbits 6 - 7 weeks old and group 2 ( old) consisted of rabbits 2 years old. Isolated bladder body strips were subjected to in vitro I/R, and the effects on contractility were determined. The strips were then frozen and stored for quantitative malondialdehyde ( MDA) analysis. Results: Contractile responses of young and old rabbit bladders to all forms of stimulation - field stimulation ( FS), carbachol and potassium chloride ( KCl) - were equal. The rate of tension to 32 Hz FS was significantly higher for group 1 in comparison with group 2. The old and young rabbits were equally sensitive to I/R in regard to FS, but the old rabbits were more sensitive to I/R in regard to carbachol and KCl stimulation. Basal MDA concentration of both young and aged bladder strips were similar. Ischemia mediated a significant increase in MDA in bladder strips from both young and old rabbits, but the MDA level was significantly greater for the young than for the old. Conclusion: Although the level of oxidative damage was greater in the young rabbit bladders, functionally, the old rabbit bladders were more sensitive to I/ R damage. Copyright (c) 2007 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000098075
dc.identifier.endpage159en_US
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.issue2en_US
dc.identifier.pmid17293657en_US
dc.identifier.scopus2-s2.0-33846930121en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1159/000098075
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6178
dc.identifier.volume78en_US
dc.identifier.wosWOS:000244109400012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAğartan, Canan Aldırmaz
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder Dysfunctionen_US
dc.subjectIschemia/reperfusionen_US
dc.subjectMalondialdehydeen_US
dc.titleEffect of age on the response to in vitro ischemia and reperfusion of the rabbit bladderen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu