Zinc sulfate and/or growth hormone administration for the prevention of radiation-induced dermatitis: a placebo-controlled rat model study

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dc.authorid0000-0003-1106-6227
dc.authorid0000-0003-0076-4716
dc.authorid0000-0002-9414-2178
dc.authorid0000-0002-5650-1280
dc.contributor.authorKandaz, Mustafa
dc.contributor.authorErtekin, Mustafa Vecdi
dc.contributor.authorKarslıoğlu, İhsan
dc.contributor.authorErdoğan, Fazlı
dc.contributor.authorSezen, Orhan
dc.contributor.authorGepdiremen, Akçahan
dc.date.accessioned2021-06-23T19:45:32Z
dc.date.available2021-06-23T19:45:32Z
dc.date.issued2017
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractGrowth hormone (GH) and zinc (Zn) were evaluated for their potential to prevent radiation injury using a rat model of radiation-induced skin injury. Sprague-Dawley rats were divided into five groups: a control group not receiving Zn, GH, or irradiation: a radiation (RT) group receiving a single 30 Gy dose of gamma irradiation to the right hind legs; a radiation + GH group (RT + GH) receiving a single 30 Gy dose of gamma irradiation plus the subcutaneous administration of 0.01 IU kg d(-1) GH; a radiation + Zn group (RT + Zn) receiving a single 30 Gy dose plus 5 mg kg d(-1) Zn po; and a radiation + GH + Zn group (RT + GH + Zn) group receiving a single 30 Gy dose plus subcutaneous 0.01 IU kg d(-1) GH and 5 mg kg d(-1) Zn po. Acute skin reactions were assessed every 3 days by two radiation oncologists grouping. Light microscopic findings were assessed blindly by two pathologists. Groups receiving irradiation were associated with dermatitis as compared to the control group (P < 0.05). The severity of radiodermatitis in the RT + GH, RT + Zn, and RT + GH + Zn groups was significantly lower than that in the RT group (P < 0.05). Furthermore, radiodermatitis was observed earlier in the RT group than in the other treatment groups (P < 0.05). GH and Zn effectively prevented epidermal atrophy, dermal degeneration, and hair follicle atrophy. The highest level of protection against radiation dermatitis was observed in the combination group.en_US
dc.identifier.doi10.1007/s12011-017-0952-z
dc.identifier.endpage116en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid28168533en_US
dc.identifier.scopus2-s2.0-85011715882en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage110en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-017-0952-z
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9170
dc.identifier.volume179en_US
dc.identifier.wosWOS:000407431600015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGepdiremen, Akçahan
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDermatitisen_US
dc.subjectRadiotherapyen_US
dc.subjectZinc Sulfateen_US
dc.subjectGrowth Hormoneen_US
dc.subjectPreventionen_US
dc.subjectRaten_US
dc.titleZinc sulfate and/or growth hormone administration for the prevention of radiation-induced dermatitis: a placebo-controlled rat model studyen_US
dc.typeArticleen_US

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