Anti-inflammatory effect of cortistatin in rat endotoxin-induced uveitis model

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dc.authorid0000-0003-4468-3985
dc.contributor.authorBalbaba, Mehmet
dc.contributor.authorDal, Ali
dc.contributor.authorÇolakoğlu, Neriman
dc.contributor.authorBulmuş, Özgür
dc.contributor.authorUlaş, Fatih
dc.contributor.authorYıldırım, Hakan
dc.contributor.authorAydemir, Orhan
dc.date.accessioned2021-06-23T19:53:56Z
dc.date.available2021-06-23T19:53:56Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To evaluate the anti-inflammatory effect of cortistatin (CST) in endotoxin-induced uveitis (EIU) model and to compare the results with corticosteroid treatment. Methods: A total of 35 healthy Wistar albino rats were randomly divided into five groups. EIU was induced by a single subcutaneous injection of lipopolysaccharide (LPS). Group I received intraperitoneal (ip) normal saline (NS), Group II received ip 150 mu g LPS plus NS, Group III received ip 150 mu g LPS plus 250 mu g/kg CST, Group IV received ip 150 mu g LPS plus 1mg/kg dexamethasone, and Group V received ip 250 mu g/kg CST only. The aqueous humor was collected 24 h after injection and the infiltrating cells were determined. Moreover, histopathological and immunohistochemical examinations were also performed. Results: The clinical score and infiltrated cell count were reduced in Groups III and IV compared with Group II (P < 0.001). The pathological findings of Groups III and IV were significantly reduced compared with Group II (P < 0.001). These findings were similar between Groups III and IV (P = 1.000). Tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) immunoreactivity in the ciliary body of Group III and Group IV were significantly reduced compared with Group II (P < 0.001). TNF-<alpha> and IL-1 beta immunoreactivity in the ciliary body of Group III and Group IV were similar compared with Group I and Group V (range of P values was 0.539-0.958). Conclusion: CST administration as a therapeutic agent might ameliorate the severity of intraocular inflammation in uveitis patients. In conclusion, effect of CST and dexamethasone in EIU model was comparable.en_US
dc.identifier.doi10.4103/ijo.IJO_290_20
dc.identifier.endpage1924en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.issue9en_US
dc.identifier.pmid32823415en_US
dc.identifier.scopus2-s2.0-85089808415en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1920en_US
dc.identifier.urihttps://doi.org/10.4103/ijo.IJO_290_20
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10339
dc.identifier.volume68en_US
dc.identifier.wosWOS:000604486400035en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlaş, Fatih
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCortistatinen_US
dc.subjectEndotoxin-induced Uveitisen_US
dc.subjectInterleukin-1en_US
dc.subjectTumor Necrosis Factor-alphaen_US
dc.titleAnti-inflammatory effect of cortistatin in rat endotoxin-induced uveitis modelen_US
dc.typeArticleen_US

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