Pulsed magnetic field treatment ameliorates the progression of peripheral neuropathy by modulating the neuronal oxidative stress, apoptosis and angiogenesis in a rat model of experimental diabetes

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dc.authorid0000-0002-5926-9210en_US
dc.authorid0000-0002-3233-8044en_US
dc.authorid0000-0001-8312-5156en_US
dc.authorid0000-0002-9301-9119
dc.contributor.authorMert, Tufan
dc.contributor.authorŞahin, Emel
dc.contributor.authorYaman, Selma
dc.contributor.authorŞahin, Mehmet
dc.date.accessioned2021-06-23T19:17:10Z
dc.date.available2021-06-23T19:17:10Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: The present study aimed to investigate the possible anti-neuropathic effects of daily pulsed magnetic field treatments (PMF) in streptozotocin (60 mg/kg) induced 4 weeks diabetic (type-1) wistar rats (6-8 months). Materials and methods: Body mass, blood glucose and thermal and mechanical sensations were evaluated during the PMF or sham-PMF in diabetic or non-diabetic rats (n = 7/group). After the measurements of motor nerve conduction velocities (MNCV), the levels of several biomarkers for oxidative stress, apoptosis and angiogenesis in spinal cord and sciatic nerve were measured. Results: PMF for 4 weeks significantly recovered the MCNV (96.9% and 63.9%) and almost fully (100%) restored to the latency and threshold. PMF also significantly suppressed the diabetes induced enhances in biochemical markers of both neuronal tissues. Conclusions: Findings suggested that PMF might prevent the development of functional abnormalities in diabetic rats due to its anti-oxidative, anti-apoptotic and anti-angiogenic actions in neuronal tissues.en_US
dc.identifier.doi10.1080/13813455.2020.1788098
dc.identifier.endpage8
dc.identifier.issn1381-3455
dc.identifier.pmid32633145en_US
dc.identifier.scopus2-s2.0-85087649411en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1080/13813455.2020.1788098
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5267
dc.identifier.wosWOS:000546358400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMert, Tufan
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives Of Physiology And Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulsed Magnetic Fielden_US
dc.subjectDiabetic Neuropathyen_US
dc.subjectNeuronal Biomarkersen_US
dc.subjectRaten_US
dc.titlePulsed magnetic field treatment ameliorates the progression of peripheral neuropathy by modulating the neuronal oxidative stress, apoptosis and angiogenesis in a rat model of experimental diabetesen_US
dc.typeArticleen_US

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