Transcranial magnetic stimulation during pregnancy

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dc.authorid0000-0001-5207-6240en_US
dc.authorid0000-0002-2514-5682en_US
dc.contributor.authorSayar, Gökben Hızlı
dc.contributor.authorÖzten, Eylem
dc.contributor.authorTufan, Ali Evren
dc.contributor.authorCerit, Cem
dc.contributor.authorKagan, Gaye
dc.date.accessioned2021-06-23T19:35:44Z
dc.date.available2021-06-23T19:35:44Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of the present study was to assess the safety and effectiveness of high-frequency repetitive transcranial magnetic stimulation (rTMS) in pregnant patients with depression. Thirty depressed pregnant patients received rTMS over the left prefrontal cortex for 6 days in a week, from Monday to Saturday for 3 weeks. The rTMS intensity was set at 100 % of the motor threshold. A 25-Hz stimulation with a duration of 2 s was delivered 20 times with 30-s intervals. A session comprised 1,000 magnetic pulses. Depression was rated using the 17-item Hamilton depression rating scale (HAMD) before and after treatment. Response was defined as a 50 % reduction of the HAMD score. Patients with HAMD scores less than 8 were considered to be in remission. The mean HAMD score for the study group decreased from 26.77 +/- 5.58 to 13.03 +/- 6.93 (p < 0.001) after 18 sessions of rTMS. After the treatment period, 41.4 % of the study group demonstrated significant mood improvements as indexed by a reduction of more than 50 % on the HAMD score. In addition, 20.7 % attained remission (HAMD score < 8), 34.5 % achieved a partial response, and 3.4 % had worsening in HAMD scores at the end of treatment. Treatment was well tolerated, and no significant adverse effects were reported. rTMS was well tolerated and found to be statistically and clinically effective in pregnant patients with treatment-resistant depression. This study contributed to the existing evidence of the antidepressant effect of rTMS in the treatment of depression in pregnancy.en_US
dc.identifier.doi10.1007/s00737-013-0397-0
dc.identifier.endpage315en_US
dc.identifier.issn1434-1816
dc.identifier.issn1435-1102
dc.identifier.issue4en_US
dc.identifier.pmid24248413en_US
dc.identifier.scopus2-s2.0-84904408742en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://doi.org/10.1007/s00737-013-0397-0
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7854
dc.identifier.volume17en_US
dc.identifier.wosWOS:000339381100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTufan, Ali Evren
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofArchives Of Womens Mental Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRepetitive Transcranial Magnetic Stimulationen_US
dc.subjectrTMSen_US
dc.subjectPregnancyen_US
dc.subjectDepressionen_US
dc.subjectTreatmenten_US
dc.titleTranscranial magnetic stimulation during pregnancyen_US
dc.typeArticleen_US

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