Bone mineral density and serum vitamin d status in parkinson's disease: Are the stage and clinical features of the disease Important?

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dc.authorid0000-0002-0524-2856en_US
dc.authorid0000-0001-5436-8618en_US
dc.authorid0000-0003-0290-9341en_US
dc.contributor.authorÖztürk, Erhan Arif
dc.contributor.authorGündoğdu, İbrahim
dc.contributor.authorTonuk, Burak
dc.contributor.authorUmay, Ebru
dc.contributor.authorKoçer, Bilge Gönenli
dc.contributor.authorÇakcı, Aytül
dc.date.accessioned2021-06-23T19:54:28Z
dc.date.available2021-06-23T19:54:28Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Although it is well known that patients with Parkinson's disease (PD) have low bone mineral density (BMD) and serum vitamin D level, there are no studies evaluating their relationship with the stage and clinical features of the PD. Objective: The purpose of this study was to evaluate the relationship between BMD and serum vitamin D level and stage or clinical features of the PD. Materials and Methods: One hundred twenty-four patients with PD recruited from Movement Disorders Outpatient Clinic and age- and sex-matched 116 healthy controls were included in the study. BMD and serum vitamin D level of all participants were measured. After patients had been divided into four groups according to Hoehn and Yahr (H and Y) staging, a total of 5 groups with controls, BMD (lumbar and femoral) and serum vitamin D level were compared between groups. The relationship between the clinical features of the PD [disease duration, medication history, Unified Parkinson's Disease Rating Scale (UPDRS) part II and III, and subscores of UPDRS part III] and BMD or vitamin D was investigated. Results: Lumbar and femoral BMD values and serum vitamin D level were significantly lower in patients with PD compared to controls. Low BMD and low serum vitamin D level were identified in the early stages of the disease (H and Y stage 1 and 1.5) and were marked by the progress of the stage of the disease. There was a negative relationship between the clinical features of the PD and both BMD and serum vitamin D level. Conclusion: All patients with PD should be screened for developing osteoporosis and for sufficient vitamin D level in the early stages of the disease. Preventive methods for bone quality should be taken into consideration at the onset of PD.en_US
dc.identifier.doi10.4103/0028-3886.283755
dc.identifier.endpage400en_US
dc.identifier.issn0028-3886
dc.identifier.issn1998-4022
dc.identifier.issue2en_US
dc.identifier.pmid32415013en_US
dc.identifier.scopus2-s2.0-85084786346en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage394en_US
dc.identifier.urihttps://doi.org/10.4103/0028-3886.283755
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10550
dc.identifier.urihttps://www.proquest.com/publiccontent/docview/2404571502
dc.identifier.volume68en_US
dc.identifier.wosWOS:000568236900033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTonuk, Burak
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNeurology Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Mineral Densityen_US
dc.subjectClinical Characteristicsen_US
dc.subjectHoehn and Yahr Stageen_US
dc.subjectParkinson's Diseaseen_US
dc.subjectSerum Vitamin Den_US
dc.titleBone mineral density and serum vitamin d status in parkinson's disease: Are the stage and clinical features of the disease Important?en_US
dc.typeArticleen_US

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