Type-2 diabetes and coronary heart disease: Common physiopathology, viewed from autoimmunity

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dc.authorid0000-0002-5716-1193
dc.contributor.authorOnat, Altan
dc.contributor.authorDönmez, İbrahim
dc.contributor.authorKaradeniz, Yusuf
dc.contributor.authorÇakir, Hakan
dc.contributor.authorKaya, Ayşem
dc.date.accessioned2021-06-23T18:55:36Z
dc.date.available2021-06-23T18:55:36Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractTwo highly prevalent diseases, Type-2 diabetes mellitus and coronary heart disease (CHD), share risk factors. Excess levels of LDL-cholesterol have been overemphasized to uniformly encompass the development of CHD, and the origin of insulin resistance underlying Type-2 diabetes has not been fully elucidated. Autoimmune response has been recognized to be responsible only of a small minority of diabetes. The increasing trend in the worldwide prevalence of diabetes and the risk factors for both diseases are reviewed, the independent mediation for CHD of (central) adiposity in both diseases and the 'hypertriglyceridemic waist' phenotype are outlined. Evidence is described that serum lipoprotein (Lp)(a) concentrations, not only in excess, but also in apparently 'reduced' levels, as a result of autoimmune response, underlie both disorders and are closely related to insulin resistance. © 2014 Informa UK, Ltd.en_US
dc.identifier.doi10.1586/14779072.2014.910114
dc.identifier.endpage679en_US
dc.identifier.issn1477-9072
dc.identifier.issue6en_US
dc.identifier.pmid24846677en_US
dc.identifier.scopus2-s2.0-84901437881en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage667en_US
dc.identifier.urihttps://doi.org/10.1586/14779072.2014.910114
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4816
dc.identifier.volume12en_US
dc.identifier.wosWOS:000216653100006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDönmez, İbrahim
dc.language.isoenen_US
dc.publisherExpert Reviews Ltd.en_US
dc.relation.ispartofExpert Review of Cardiovascular Therapyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmune Activationen_US
dc.subjectCoronary Heart Diseaseen_US
dc.subjectPrimary Preventionen_US
dc.subjectProinflammatory Stateen_US
dc.subjectStatin Therapyen_US
dc.titleType-2 diabetes and coronary heart disease: Common physiopathology, viewed from autoimmunityen_US
dc.typeReview Articleen_US

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Scopus İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
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