Effects of exopolysaccharide-producing probiotic strains on experimental colitis in rats

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dc.authorid0000-0002-3487-1264
dc.authorid0000-0002-0595-7237
dc.authorid0000-0002-8647-1545
dc.contributor.authorŞengül, Neriman
dc.contributor.authorAslım, Belma
dc.contributor.authorUçar, Gülberk
dc.contributor.authorYücel, Nihal
dc.contributor.authorIşık, Sevil
dc.contributor.authorBozkurt, Hatice
dc.contributor.authorSakaoğulları, Zişan
dc.date.accessioned2021-06-23T19:19:22Z
dc.date.available2021-06-23T19:19:22Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPURPOSE: Inflammatory bowel disease is suggested to result from a dysregulated immune response toward intestinal microflora, which may be restored by probiotic therapy based on the concept of healthy microflora. Ideal probiotic bacteria may be beneficial in inflammatory bowel disease; however, the mechanism of action and the clinical efficacy of probiotic usage are still unclear. In the present study, the effect of exopolysaccharide producing probiotics was evaluated on an experimental colitis model in rats. METHODS: Colitis was induced by intracolonic administration of acetic acid. Then, rats were treated daily with two probiotic strains, Lactobacillus delbrueckii subsp. bulgaricus B3 strain ( exopolysaccharide of 211 mg/l: high- EPS group) or Lactobacillus delbrueckii subsp. bulgaricus A13 strain ( EPS of 27 mg/ l: low- EPS group), which were given into the stomach. The non-colitis-fed control group was only treated with high- exopolysaccharide strain. The model-control and control groups were treated only with tap water. Rats were killed after a seven-day treatment period. Disease activity was quantified by use of histologic scores and colonic myeloperoxidase activity, which is a marker of neutrophil infiltration during inflammation. RESULTS: The enhanced inflammatory response was accompanied by a higher level of myeloperoxidase activity in the colitis group. Histologic scores of colonic damage and myeloperoxidase activity were lower in both probiotic- treated groups compared with those of the colitis control group (P < 0.001), although the mentioned scores improved significantly more in the high- EPS group than in the low- EPS group (P < 0.001). CONCLUSIONS: Exopolysaccharide- producing probiotics significantly attenuate experimental colitis, which may be mediated by exopolysaccharide in a dose-dependent manner. Therefore, exopolysaccharide- producing probiotics may be a promising therapeutic role in inflammatory bowel disease.en_US
dc.identifier.doi10.1007/s10350-005-0267-6
dc.identifier.endpage258en_US
dc.identifier.issn0012-3706
dc.identifier.issn1530-0358
dc.identifier.issue2en_US
dc.identifier.pmid16362802en_US
dc.identifier.scopus2-s2.0-32344451370en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage250en_US
dc.identifier.urihttps://doi.org/10.1007/s10350-005-0267-6
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5928
dc.identifier.volume49en_US
dc.identifier.wosWOS:000235219600015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞengül, Neriman
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofDiseases Of The Colon & Rectumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.subjectExperimental Colitisen_US
dc.subjectProbioticsen_US
dc.subjectExopolysaccharideen_US
dc.titleEffects of exopolysaccharide-producing probiotic strains on experimental colitis in ratsen_US
dc.typeArticleen_US

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