Sesamol ameliorates acute kidney injury resulting from complete unilateral ureteral obstruction in the rats

dc.authorid0000-0002-4313-8478en_US
dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-8304-5674en_US
dc.authorid0000-0001-5608-5742en_US
dc.authorid0000-0001-5400-0012en_US
dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorBostancı, Emre
dc.contributor.authorErimşah, Sevilay
dc.contributor.authorÖztürk, Hayrettin
dc.date.accessioned2023-05-24T07:13:53Z
dc.date.available2023-05-24T07:13:53Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: We aimed to evaluate the effectiveness of sesamol in preventing the progressive renal damage caused by complete unilateral ureter obstruction (CUUO). Methods: Twenty four Wistar rats were separated into three groups: In the group 1 rats (the sham-control, n = 8), the ureters were exposed and manipulated, but not ligated. In the group 2 rats (CUUO-untreated, n=8), CUOO was accomplished by double-ligating the left ureter using 5-0 silk ties. In the group 3 rats (CUUO -Sesamol treated, n=8), CUOO was created as in the Group 2 rats, also given sesamol daily, commencing on the day of CUUO surgery. The rats' left kidneys were examined histologically and biochemically within the 8th day Results: Histopathological total score, apoptotic index and MDA values in the group 2 show a significant increase when compared to the group 1. These values were significantly decreased in the group 3 rats when compared to the group 2 rats. Tissue GPx value in the group 2 show a significant decrease when compared to Sham-control group. However, these values were significantly increased in the group 3 rats when compared to the rats 2. Polymorph nuclear leukocyte infiltration in peritubular areas was observed in group II, with moderate interstitial fibrosis and tubular dilatation. Despite the presence of dilated tubule structures in group III, this group showed less bleeding, leukocyte infiltration, and fibrosis than group II. Conclusion: The results of this study have shown that CUOO-induced renal damage can be reduced using sesamol, possibly due to its antioxidant properties. The mechanism by which sesamol causes these effects merits further investigation.en_US
dc.identifier.citationUYETURK, U., ÇETINKAYA, A., BOSTANCI, E., ERIMSAH, S., & OZTURK, H. Sesamol ameliorates acute kidney injury resulting from complete unilateral ureteral obstruction in the rats.en_US
dc.identifier.doi10.53350/pjmhs211572338
dc.identifier.endpage2342en_US
dc.identifier.issn1996-7195
dc.identifier.issue7en_US
dc.identifier.startpage2338en_US
dc.identifier.urihttp://dx.doi.org/10.53350/pjmhs211572338
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10939
dc.identifier.volume15en_US
dc.identifier.wosWOS:000709944600111en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorÜyetürk, Uğur
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorBostancı, Emre
dc.institutionauthorErimşah, Sevilay
dc.institutionauthorÖztürk, Hayrettin
dc.language.isoenen_US
dc.publisherLahore Medical Research Center LLPen_US
dc.relation.ispartofPakistan Journal Of Medical & Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComplete Unilateral Ureteral Obstructionen_US
dc.subjectRenal Damageen_US
dc.subjectSesamolen_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.titleSesamol ameliorates acute kidney injury resulting from complete unilateral ureteral obstruction in the ratsen_US
dc.typeArticleen_US

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