The HbA1c/C-peptide ratio is associated with the no-reflow phenomenon in patients with ST-elevation myocardial infarction

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dc.authorid0000-0001-8923-8709en_US
dc.authorid0000-0002-4297-1820en_US
dc.authorid0000-0002-3183-5815en_US
dc.authorid0000-0003-1784-3584en_US
dc.contributor.authorToprak, Kenan
dc.contributor.authorKaplangoray, Mustafa
dc.contributor.authorMemioğlu, Tolga
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorOmar, Bahadır
dc.contributor.authorErmiş, Mehmet Fatih
dc.date.accessioned2024-07-10T09:04:11Z
dc.date.available2024-07-10T09:04:11Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractCurrently, the gold standard treatment for ST-elevation myocardial infarction (STEMI) is primary percutaneous coronary intervention (pPCI), but even after successful pPCI, a perfusion disorder in the epicardial coronary arteries, termed no-reflow phenomenon (NR), can develop, resulting in short- and long-term adverse events. The present study assessed the relationship between NR and HbA1c/C-peptide ratio (HCR) in 1834 consecutive patients who underwent pPCI due to STEMI. Participants were divided into two groups according to NR status and the demographic, clinical and periprocedural characteristics of the groups were compared. NR developed in 352 (19.1%) of the patients in the study. While C-peptide levels were significantly lower in the NR group, HbA1c and HCR were significantly higher (P < .001, for all). In multivariable analysis, C-peptide, HbA1c, and HCR, were determined as independent predictors for NR (P < .05, for all). In Receiver Operating Characteristic (ROC) analysis, HCR predicted the NR with 80% specificity and 77% sensitivity. In STEMI patients, combining HbA1c and C-peptide in a single fraction has a predictive value for NR independent of diabetes. This ratio may contribute to risk stratification of STEMI patients.en_US
dc.identifier.citationToprak, K., Kaplangoray, M., Memioğlu, T., İnanır, M., Omar, B., Ermiş, M. F., ... & Demirbağ, R. (2023). The HbA1c/C-peptide ratio is associated with the No-reflow phenomenon in patients with ST-elevation myocardial infarction. Angiology, 00033197231213166.en_US
dc.identifier.doi10.1177/00033197231213166
dc.identifier.endpage11en_US
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.pmid37920902en_US
dc.identifier.scopus2-s2.0-85176007753en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1177/00033197231213166
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12251
dc.identifier.wosWOS:001098567900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMemioğlu, Tolga
dc.institutionauthorİnanır, Mehme
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAngiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-Peptideen_US
dc.subjectHbA1cen_US
dc.subjectNo-Reflowen_US
dc.subjectST-Elevation Myocardial Infarctionen_US
dc.subjectPrimary Percutaneous Coronary Interventionen_US
dc.titleThe HbA1c/C-peptide ratio is associated with the no-reflow phenomenon in patients with ST-elevation myocardial infarctionen_US
dc.typeArticleen_US

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