Pyridoxine may protect the cerebellar granular cells against glutamate-induced toxicity

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dc.authorid0000-0002-5650-1280
dc.authorid0000-0003-1735-4318
dc.contributor.authorBüyükokuroğlu, Mehmet Emin
dc.contributor.authorGepdiremen, Ali Akçahan
dc.contributor.authorTaştekin, Ayhan
dc.contributor.authorÖrs, Rahmi
dc.date.accessioned2021-06-23T18:54:08Z
dc.date.available2021-06-23T18:54:08Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractIn the present study, the possible protective effect of the pyridoxine against glutamate-induced neurotoxicity in cerebellar granular cell culture of rat pups is investigated for its therapeutic potential. Glutamate (10 -7 M) was administered to cerebellar granular cell cultures that were prepared from one-day-old Sprague-Dawley rats. The neuroprotective effect of pyridoxine was examined. Pyridoxine at the doses of 10-8, 10 -7, 10-6, and 10-5 M was introduced into the culture flasks before inclusion of glutamate. Pyridoxine at the doses of 10 -8 M and 10-7 M significantly reduced glutamate cytotoxicity. A 10-7 M dose of pyridoxine proved to be more effective than a 10-8 M dose. The present study demonstrates that pyridoxine may protect glutamate-induced neurotoxicity. Neuroprotective effect of pyridoxine, at least in part, may result from its anti-glutamatergic activity. Pyridoxine merits further investigation as a therapeutic option in hypoxic-ischemic brain injury. © Hogrefe & Huber Publishers.en_US
dc.identifier.doi10.1024/0300-9831.77.5.336
dc.identifier.endpage340en_US
dc.identifier.issn0300-9831
dc.identifier.issue5en_US
dc.identifier.pmid18453318en_US
dc.identifier.scopus2-s2.0-38849201219en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage336en_US
dc.identifier.urihttps://doi.org/10.1024/0300-9831.77.5.336
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4258
dc.identifier.volume77en_US
dc.identifier.wosWOS:000253027200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGepdiremen, Ali Akçahan
dc.language.isoenen_US
dc.relation.ispartofInternational Journal for Vitamin and Nutrition Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCultureen_US
dc.subjectGlutamateen_US
dc.subjectNeuronen_US
dc.subjectPyridoxineen_US
dc.subjectRaten_US
dc.titlePyridoxine may protect the cerebellar granular cells against glutamate-induced toxicityen_US
dc.typeArticleen_US

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