In vivo exposure of Albendazole sulphoxide by Haemonchus contortus and correlation between plasma and target tissue or gastrointestinal content dispositions in goats

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dc.authorid0000-0002-4912-7307en_US
dc.authorid0000-0001-8741-5548en_US
dc.authorid0000-0003-0570-2514en_US
dc.authorid0000-0001-6529-3930en_US
dc.authorid0000-0002-7776-5373en_US
dc.contributor.authorGökbulut, Cengiz
dc.contributor.authorÇırak, Veli Yılgör
dc.contributor.authorAypak, Süleyman
dc.contributor.authorAvcı, Hamdi
dc.contributor.authorAyaz, Erol
dc.date.accessioned2023-06-20T06:41:31Z
dc.date.available2023-06-20T06:41:31Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionThis study was supported by The Scientific and Technical Research Council of Turkey (TUBITAK) under grant no: 109 O 862.en_US
dc.description.abstractSheep and goats are sharing different helminth parasites including Haemonchus contortus. Control of these helminths is based mainly on the use of anthelmintics. However, in goats, the application of anthelmintics is often carried out mainly at dosages determined for sheep without knowing the real effects and metabolism features. One of the several anthelmintic classes used against these parasites is (pro) benzimidazoles which are still widely in use in small ruminants in many countries. The objective of this study was to determine (i) the correlation between plasma and tissue or gastrointestinal content dispositions of ricobendazole (RBZ) in goats and (ii) the in vivo exposure of ricobendazole by H. contortus. Ten goats were experimentally infected with 10,000 larvae of H. contortus. Four weeks of post-infection, the animals received RBZ subcutaneously at 5 mg/kg body weight. Two goats were sacrificed per time at 1, 2, 4, 6 and 12 h after drug administration and, blood, bile, urine, liver, lung, muscle and kidney gastrointestinal tissues/fluids were collected. Adult H. contortus were collected from abomasum, and all samples were analysed by HPLC system. Ricobendazole (RBZ) and its sulphone metabolite were extensively excreted by urine and distributed to all tissues and digestive tract, mainly into the abomasum fluid. RBZ concentration in the lung and ABZSO(2) in the kidney were relatively higher than those of other tissues, respectively. The parent drug and its metabolite were recovered in both male and female H. contortus. This study indicates that in goats the plasma concentration profiles of RBZ are strongly correlated with those achieved in different target tissues or fluids, which in turn, reflect the amount of drug taken up by parasites.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [109 O 862]en_US
dc.identifier.citationGokbulut, C., Cirak, V. Y., Aypak, S., Avci, H., Sekkin, S., Yalinkilinc, H. S., ... & Ayaz, E. (2021). In vivo exposure of Albendazole sulphoxide by Haemonchus contortus and correlation between plasma and target tissue or gastrointestinal content dispositions in goats. Journal of Veterinary Pharmacology and Therapeutics, 44(5), 799-807.en_US
dc.identifier.doi10.1111/jvp.12974
dc.identifier.endpage807en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue5en_US
dc.identifier.pmid33893651en_US
dc.identifier.scopus2-s2.0-85104812877en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage799en_US
dc.identifier.urihttp://dx.doi.org/10.1111/jvp.12974
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11145
dc.identifier.volume44en_US
dc.identifier.wosWOS:000643136100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAyaz, Erol
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitak[109 O 862]
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlbendazole Sulphoxideen_US
dc.subjectBenzimidazolesen_US
dc.subjectGoaten_US
dc.subjectHaemonchus Contortusen_US
dc.subjectRicobendazoleen_US
dc.titleIn vivo exposure of Albendazole sulphoxide by Haemonchus contortus and correlation between plasma and target tissue or gastrointestinal content dispositions in goatsen_US
dc.typeArticleen_US

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