Effect of mitomycin, bevacizumab, and 5-Fluorouracil to inhibit urethral fibrosis in a rabbit model

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dc.authorid0000-0002-4313-8478
dc.authorid0000-0001-7858-0672
dc.authorid0000-0003-1698-8263
dc.authorid
dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorGücük, Adnan
dc.contributor.authorFırat, Tülin
dc.contributor.authorKemahlı, Eray
dc.contributor.authorKükner, Aysel
dc.contributor.authorÖzyalvaçlı, Mehmet Emin
dc.date.accessioned2021-06-23T19:35:23Z
dc.date.available2021-06-23T19:35:23Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and Purpose: Mitomycin C (MMC), bevacizumab, and 5-fluorouracil (5-FU) are frequently used in cancer treatment. Each of these agents also exhibits antiproliferative properties in different tissues. We compared the efficacy of MMC, bevacizumab, and 5-FU may inhibit urethral fibrosis (UF) without statistically significant differences among them. Materials and Methods: Forty male rabbits with traumatized urethras were divided into four groups: Group 1 (control), no medical treatment; group 2, MMC applied to the traumatized area; group 3, bevacizumab applied to the traumatized area; and group 4, 5-FU applied to the traumatized area. All animals were euthanized after 28 days to evaluate the presence of chronic inflammation and fibrosis. Tissue samples were subjected to hematoxylin and eosin and Masson trichrome staining to assess the presence of fibrosis, the state of the epithelium, and collagen density. Results: The MMC and control groups showed the most significant difference in outcomes (P<0.001), followed by the bevacizumab (P=0.002) and 5-FU groups (P=0.005). No statistically significant difference was noted when all three treatment groups were compared with one another. Histopathologic examination revealed inflammatory cell infiltration in the connective tissue, irregular collagen bundles, increased fibroblasts, and a moderate degree of fibrosis in the control group. Compared with controls, all treatment groups exhibited mild fibrosis, less collagen bundle irregularity, and lower numbers of fibroblasts. Conclusion: MMC, bevacizumab, and 5-FU may inhibit UF. There were no statistically significant differences in the effectiveness among the three agents.en_US
dc.identifier.doi10.1089/end.2014.0420
dc.identifier.endpage1367en_US
dc.identifier.issn0892-7790
dc.identifier.issn1557-900X
dc.identifier.issue11en_US
dc.identifier.pmid25026189en_US
dc.identifier.startpage1363en_US
dc.identifier.urihttps://doi.org/10.1089/end.2014.0420
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7776
dc.identifier.volume28en_US
dc.identifier.wosWOS:000343979900020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜyetürk, Uğur
dc.institutionauthorGücük, Adnan
dc.institutionauthorFırat, Tülin
dc.institutionauthorKemahlı, Eray
dc.institutionauthorKükner, Aysel
dc.institutionauthorÖzyalvaçlı, Mehmet Emin
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Endourologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of mitomycin, bevacizumab, and 5-Fluorouracil to inhibit urethral fibrosis in a rabbit modelen_US
dc.typeArticleen_US

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