Effects of hormone replacement therapy on plasma and tissue fibrinolytic activity in a rat model of surgically induced menopause

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dc.authorid0000-0002-1347-8498en_US
dc.authorid0000-0002-8929-6973
dc.contributor.authorTopçuoğlu, Mehmet Ata
dc.contributor.authorAlbayrak, Mustafa
dc.contributor.authorErman, Hayriye
dc.contributor.authorBalcı, Huriye
dc.contributor.authorKarakuş, Mesut
dc.date.accessioned2021-06-23T19:35:12Z
dc.date.available2021-06-23T19:35:12Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: The purpose of this study was to analyze the effects of estrogen deficiency and hormone replacement therapy (HRT) on fibrinolytic activity in a rat mode of surgically induced menopause. Methods: Twelve-week-old, sexually mature female Sprague-Dawley rats, each weighing 200-250 g, were randomly divided into four groups: (1) sham- operated group, (2) ovariectomy group, (3) ovariectomy group followed by oral administration of daily 17 beta-estradiol (0.02 mg/kg/day) (E2) + norethisterone acetate (0.01 mg/kg/day), and (4) ovariectomy group followed by oral administration of daily 17 beta-estradiol (0.01 mg/kg/day) + drospirenone (0.02 mg/kg/day). Tissue plasminogen activator (tPA) antigen, plasminogen activator inhibitor-1 (PAI- 1) antigen, and PAI-1/tPA levels were measured as markers of fibrinolysis in plasma and liver and brain tissue. Results: Compared with sham-operated rats, ovariectomized rats showed higher levels of fibrinolytic activity; however, the increased fibrinolytic activity in plasma and liver tissue was significantly reduced by HRT regimens. No change was observed in the levels of fi brinolytic activity in brain tissue. Conclusions: HRT showed beneficial effects by decreasing fibrinolytic activity related to surgically induced menopause. Short-term HRT treatment was associated with a shift in the procoagulant-anticoagulant balance toward a procoagulant state.en_US
dc.identifier.endpageE92en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue2en_US
dc.identifier.pmid24690423en_US
dc.identifier.scopus2-s2.0-84898621563en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE85en_US
dc.identifier.urihttps://search.ebscohost.com/login.aspx?direct=true&db=asn&AN=95792036&lang=tr&site=eds-live
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7736
dc.identifier.volume37en_US
dc.identifier.wosWOS:000334296500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTopçuoğlu, Mehmet Ata
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical And Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffects of hormone replacement therapy on plasma and tissue fibrinolytic activity in a rat model of surgically induced menopauseen_US
dc.typeArticleen_US

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