Relationship between the IL-12B promoter polymorphism and allergic rhinitis, familial asthma, serum total IgE, and eosinophil level in asthma patients

dc.authorid0000-0002-2408-5294en_US
dc.authorid0000-0003-2622-5104
dc.contributor.authorTuğ, Esra
dc.contributor.authorÖzbey, U.
dc.contributor.authorTuğ, Tuncer
dc.contributor.authorYüce, H.
dc.date.accessioned2021-06-23T19:26:32Z
dc.date.available2021-06-23T19:26:32Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: IL-12B is a strong candidate gene for asthma. Objectives: We investigated the relationship between IL-12B and asthma, allergic rhinitis, familial asthma, and levels of eosinophils and total immunoglobulin (Ig) E in the serum of asthma patients. Methods:The study group consisted of 53 asthma patients and 60 control patients. Serum total IgE levels, eosinophil count, and the presence of allergic rhinitis and familial asthma were determined, and the IL-12B polymorphism was analyzed. Both patients and controls were divided into 3 groups based on their genotypes-homozygous for allele I (All), homozygous for allele 2 (A2), and heterozygous patients, ie, alleles 1 and 2 (A1A2). Each genotype was compared with the other genotypes and the control genotypes. Results: The rates for genotypes A1, A1A2, and A2 were 17%, 40%, and 43%, respectively. Male and female total IgE levels were not different between the groups (P>.05), but they were higher than in the controls (P>.05). The frequencies of allergic rhinitis and familial asthma were not different between the groups (P>.05), although allergic rhinitis in the A1A2 genotype and familial asthma in the A2 genotype were higher than in the controls (P<.05). Conclusions: Our comparison of asthma patients and controls showed that familial susceptibility to asthma may be related to the A2 genotype, whereas coexistence of asthma and allergic rhinitis may be related to the A1A2 genotype. In asthmatic patients, the effects of the IL-12B polymorphism on asthma, allergic rhinitis, familial asthma, eosinophilia and total IgE levels, are controversial. We think that there is a need to investigate this hypothesis in larger series.en_US
dc.identifier.endpage26en_US
dc.identifier.issn1018-9068
dc.identifier.issue1en_US
dc.identifier.pmid19274925en_US
dc.identifier.scopus2-s2.0-62549107524en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6578
dc.identifier.urihttp://www.jiaci.org/issues/vol19issue1/vol19issue01-4.htm
dc.identifier.volume19en_US
dc.identifier.wosWOS:000263743200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTuğ, Esra
dc.institutionauthorTuğ, Tuncer
dc.language.isoenen_US
dc.publisherEsmon Publicidad S Aen_US
dc.relation.ispartofJournal Of Investigational Allergology And Clinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergic Rhinitisen_US
dc.subjectAsthmaen_US
dc.subjectFamilial Asthmaen_US
dc.subjectIL 12B Polymorphismen_US
dc.subjectTotal IgEen_US
dc.titleRelationship between the IL-12B promoter polymorphism and allergic rhinitis, familial asthma, serum total IgE, and eosinophil level in asthma patientsen_US
dc.typeArticleen_US

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