N-Acetylcysteine in intestinal reperfusion injury: an experimental study in rats

Basit Öğe Kaydı
dc.authorid0000-0002-5916-2675en_US
dc.authorid0000-0001-5807-6698
dc.authorid0000-0002-0317-7181
dc.authorid0000-0002-4216-5773
dc.authorid0000-0002-5916-2675
dc.contributor.authorHazinedaroğlu, Selçuk M.
dc.contributor.authorDülger, Ferda
dc.contributor.authorKayaoğlu, Hüseyin A.
dc.contributor.authorPehlivan, Mevlüt
dc.contributor.authorSerinsöz, Ebru
dc.contributor.authorCanbolat, Orhan
dc.contributor.authorErverdi, Nezih
dc.date.accessioned2021-06-23T19:17:54Z
dc.date.available2021-06-23T19:17:54Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The aim of the present study was to investigate the effect of N-acetylcysteine on intestinal reperfusion injury. Methods: Forty Spraque-Dawley rats were divided into four groups (n = 10): sham, sham + N-acetylcysteine, reperfusion, and reperfusion + N-acetylcysteine. Thirty minutes of ischaemia +/- 30 min of reperfusion was performed under 100 mg/kg N-acetylcysteine or placebo, administered 30 min before the operation in the groups where appropriate. Ileum samples were resected for histopathologic evaluation and tissue malondialdehyde and super oxide dismutase level determination. Results: The mean mucosal injury score and malondialdehyde level of the reperfusion and reperfusion + N-acetylcysteine groups were significantly higher than that of the control and control + N-acetylcysteine group (P < 0.01, P < 0.05, respectively). Mean super oxide dismutase level of the control + N-acetylcysteine group was significantly higher than that of the other groups (P < 0.05). Conclusion: N-Acetylcysteine did not prevent intestinal reperfusion injury by means of histopathologic findings and malondialdehyde level.en_US
dc.identifier.doi10.1111/j.1445-1433.2004.03111.x
dc.identifier.endpage678en_US
dc.identifier.issn1445-1433
dc.identifier.issue8en_US
dc.identifier.pmid15315570en_US
dc.identifier.scopus2-s2.0-4444227435en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage676en_US
dc.identifier.urihttps://doi.org/10.1111/j.1445-1433.2004.03111.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5577
dc.identifier.volume74en_US
dc.identifier.wosWOS:000223254100016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPehlivan, Mevlüt
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAnz Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-acetylcysteineen_US
dc.subjectIntestineen_US
dc.subjectIschaemiaen_US
dc.subjectMalondialdehydeen_US
dc.subjectReperfusionen_US
dc.titleN-Acetylcysteine in intestinal reperfusion injury: an experimental study in ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
selcuk-hazinedaroglu.pdf
Boyut:
66.21 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/ Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu