Selective amplification of plasmonic sensor signal for cortisol detection using gold nanoparticles

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dc.authorid0000-0001-5173-1522en_US
dc.authorid0000-0001-7292-7241en_US
dc.authorid0000-0003-3260-1639en_US
dc.contributor.authorYılmaz, Gaye Ezgi
dc.contributor.authorSaylan, Yeseren
dc.contributor.authorGöktürk, İlgim
dc.contributor.authorYılmaz, Fatma
dc.contributor.authorDenizli, Adil
dc.date.accessioned2023-09-15T10:28:44Z
dc.date.available2023-09-15T10:28:44Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Gerede Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractHerein, gold nanoparticles (AuNP)-modified cortisol-imprinted (AuNP-MIP) plasmonic sensor was developed for signal amplification and real-time cortisol determination in both aqueous and complex solutions. Firstly, the sensor surfaces were modified with 3-(trimethoxylyl)propyl methacrylate and then pre-complex was prepared using the functional monomer N-methacryloyl-L-histidine methyl ester. The monomer solution was made ready for polymerization by adding 2-hydroxyethyl methacrylate to ethylene glycol dimethacrylate. In order to confirm the signal enhancing effect of AuNP, only cortisol-imprinted (MIP) plasmonic sensor was prepared without AuNP. To determine the selectivity efficiency of the imprinting process, the non-imprinted (AuNP-NIP) plasmonic sensor was also prepared without cortisol. The characterization studies of the sensors were performed with atomic force microscopy and contact angle measurements. The kinetic analysis of the AuNP-MIP plasmonic sensor exhibited a high correlation coefficient (R-2 = 0.97) for a wide range (0.01-100 ppb) with a low detection limit (0.0087 ppb) for cortisol detection. Moreover, the high imprinting efficiency (k ' = 9.67) of the AuNP-MIP plasmonic sensor was determined by comparison with the AuNP-NIP plasmonic sensor. All kinetic results were validated and confirmed by HPLC.en_US
dc.identifier.citationYılmaz, G. E., Saylan, Y., Göktürk, I., Yılmaz, F., & Denizli, A. (2022). Selective amplification of plasmonic sensor signal for cortisol detection using gold nanoparticles. Biosensors, 12(7), 482.en_US
dc.identifier.doi10.3390/bios12070482
dc.identifier.endpage15en_US
dc.identifier.issn2079-6374
dc.identifier.issue7en_US
dc.identifier.pmid35884285en_US
dc.identifier.scopus2-s2.0-85134377559en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.3390/bios12070482
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11706
dc.identifier.volume12en_US
dc.identifier.wosWOS:000833263800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Fatma
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofBiosensors-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCortisol Detectionen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectMolecular Imprintingen_US
dc.subjectPlasmonic Sensoren_US
dc.subjectSalivary Cortisolen_US
dc.subjectElectrochemical Immunosensoren_US
dc.titleSelective amplification of plasmonic sensor signal for cortisol detection using gold nanoparticlesen_US
dc.typeArticleen_US

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