Biological evaluation and phytochemical profiling of some lichen species

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dc.authorid0000-0001-5306-8584en_US
dc.authorid0000-0001-5306-8584
dc.authorid0000-0001-7712-2813
dc.authorid0000-0002-8933-9590
dc.authorid0000-0002-3549-2872
dc.contributor.authorTaş, İsa
dc.contributor.authorYıldırım, Arzu Birinci
dc.contributor.authorÖzkan, Erva
dc.contributor.authorÖzyiğitoğlu, Gülşah Çobanoğlu
dc.contributor.authorYavuz, Muhsine Zeynep
dc.contributor.authorTürker, Arzu Uçar
dc.date.accessioned2021-06-23T19:50:31Z
dc.date.available2021-06-23T19:50:31Z
dc.date.issued2019
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractLichens are a symbiotic relationship between a fungus and a photosynthetic partner. Chemical characterization and bioactive potentials (antiproliferative, antioxidant, and antibacterial) of five lichen species (Evernia prunastri, Platismatia glauca, Pseudevernia furfuracea, Ramalina fastigiata, and Ramalina farinacea) were assessed. Five lichen metabolites (usnic acid, atranorin, stictic acid, evernic acid, and fumarprotocetraric acid) were analyzed by HPLC-DAD. E. prunastri was noteworthy evernic acid source. Antiproliferative activity was evaluated using human breast adenocarcinoma (MCF-7) and human hepatocellular carcinoma (HepG2/C3A) cell lines. The strongest activity was observed for P. glauca against HepG2/C3A, while the only lichen species that induced cytotoxicity against MCF-7 cell line was P. futfuracea. The highest antioxidant activity was also obtained with P. furfuracea. E. prunastri and R. farinaceae had the highest phenolic and flavonoid contents, respectively. Antibacterial activities of the extracts were determined against ten pathogenic bacteria. The most effective antibacterial agent was methanol extract of R. fastigiata. Our findings have revealed the pharmaceutical potentials of tested lichen species.en_US
dc.identifier.doi10.1556/066.2019.48.4.7
dc.identifier.endpage465en_US
dc.identifier.issn0139-3006
dc.identifier.issn1588-2535
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85079228028en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1556/066.2019.48.4.7
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9804
dc.identifier.volume48en_US
dc.identifier.wosWOS:000499075600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTaş, İsa
dc.institutionauthorYıldırım, Arzu Birinci
dc.institutionauthorÖzkan, Erva
dc.institutionauthorYavuz, Muhsine Zeynep
dc.institutionauthorTürker, Arzu Uçar
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Alimentariaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectAntioxidanten_US
dc.subjectAntiproliferativeen_US
dc.subjectChemical Profileen_US
dc.subjectHPLCen_US
dc.subjectLichenen_US
dc.titleBiological evaluation and phytochemical profiling of some lichen speciesen_US
dc.typeArticleen_US

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