The role of cell adhesion molecules in ischemic epididymal injury

dc.authorid0000-0001-5608-5742
dc.authorid0000-0001-9277-9119
dc.authorid0000-0002-1162-5140
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorDokucu, Ali İhsan
dc.date.accessioned2021-06-23T19:25:54Z
dc.date.available2021-06-23T19:25:54Z
dc.date.issued2008
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective The aim of this study was to investigate the role of adhesion molecules in epididymal injury induced by ischemia-reperfusion (I-R) in the rats. Study design About 20 male Sprague-Dawley rats were separated into two groups. A sham operation was performed in group 1 (control). In group 2 (I-R), following 6 h of unilateral spermatic cord torsion, 1-h detorsion of the testis was performed. Then, epididymides were removed to measure the tissue levels of malondialdehyde (MDA) and to make histological examination. Results Malondialdehyde values increased in group 2. In group 2, the rats demonstrated significant disorganization of the epithelium and loss of microvilli in the epididymal tissue. No abnormal microscopic findings of the epididymis of the rats in the control group. The tenascin expression in the interstitial area of the epididymis was intense in group 2. Intercellular adhesion molecule-1 (ICAM-1) expression by intense brown staining was seen along the basement membrane in epididymal tissue from I-R group rats. The microvillus sites of the epithelia in I-R group were stained mildly by lectin. Conclusion The increased expression of adhesion molecules found in epididymal injury induced during of postischemic reperfusion may implicate importance of inflammatory infiltration.en_US
dc.identifier.doi10.1007/s11255-007-9243-5
dc.identifier.endpage142en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue1en_US
dc.identifier.pmid17657579en_US
dc.identifier.scopus2-s2.0-41549158307en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-007-9243-5
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6314
dc.identifier.volume40en_US
dc.identifier.wosWOS:000254089300023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, Hayrettin
dc.language.isoenen_US
dc.publisherSpringer Nature B.V.en_US
dc.relation.ispartofInternational Urology And Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular and Spermatic Cord Torsionen_US
dc.subjectAdhesion Moleculesen_US
dc.subjectRaten_US
dc.titleThe role of cell adhesion molecules in ischemic epididymal injuryen_US
dc.typeArticleen_US

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