Increased epicardial adipose tissue thickness is associated with microalbuminuria in hypertensive patients with left ventricular hypertrophy

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dc.authorid0000-0002-2159-064Xen_US
dc.authorid0000-0003-1784-3584
dc.contributor.authorEren, Hayati
dc.contributor.authorOmar, Muhammed Bahadır
dc.contributor.authorKaya, Ülker
dc.contributor.authorÖcal, Lütfi
dc.contributor.authorİnanır, Mehmet
dc.contributor.authorÖcal, Asli Gözek
dc.contributor.authorGenç, Ömer
dc.date.accessioned2021-06-23T19:55:16Z
dc.date.available2021-06-23T19:55:16Z
dc.date.issued2021
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective Epicardial adipose tissue (EAT) is a cardiometabolic risk factor, and its possible relationship with hypertension has been previously reported. Microalbuminuria (MA) is associated with target-organ damage, especially in patients with hypertension with left ventricular hypertrophy (LVH) and suggest endothelial dysfunction. This study aimed to investigate the relationship between echocardiographic EAT thickness and presence of MA in patients with hypertension. Methods A total of 297 newly diagnosed hypertension patients who applied to the outpatient clinic were enrolled consecutively in this study. Patients were divided into two groups regarding the presence of LVH in echocardiography. An age and gender matched control group was set including 156 healthy patients without HT. All subjects underwent transthoracic echocardiography for the measurement of EAT thickness. Spot urine samples were collected for the assessment of MA. Results In hypertensive patients with LVH, the EAT thicknesses (6.6 +/- 1.8 vs 5.3 +/- 1.5 vs 5.1 +/- 1.3, p < .001; respectively) and prevalence of MA (41.2 vs 20.1 vs 3.2%; p < .001 respectively) were significantly higher than the other two groups. In hypertensive patiens without LVH, no relationship was found between the presence of MA and EAT thickness. In multivariate regression analyses, EAT thickness (OR: 3.141, 95%CI: 2.425-6.123,p< .001) and left ventricular mass index (OR: 1.339, 95%CI: 1.145-2.143,p= .003) were determined as independent predictors for MA development in hypertensive patients with LVH. Conclusion Measurement of EAT thickness may help to identify high-risk hypertensive patients for target-organ damage especially among patients with LVH.en_US
dc.identifier.doi10.1080/10641963.2020.1790588
dc.identifier.endpage25en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue1en_US
dc.identifier.pmid32657169en_US
dc.identifier.scopus2-s2.0-85087870971en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage18en_US
dc.identifier.urihttps://doi.org/10.1080/10641963.2020.1790588
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10766
dc.identifier.volume43en_US
dc.identifier.wosWOS:000551490100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİnanır, Mehmet
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofClinical And Experimental Hypertensionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEchocardiographyen_US
dc.subjectEpicardial Adipose Tissueen_US
dc.subjectHypertensionen_US
dc.subjectLeft Ventricular Hypertrophyen_US
dc.subjectMicroalbuminuriaen_US
dc.titleIncreased epicardial adipose tissue thickness is associated with microalbuminuria in hypertensive patients with left ventricular hypertrophyen_US
dc.typeArticleen_US

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