The effects of moxidectin nicotine-conditioned cue on nicotine-seeking behavior in mice

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dc.authorid0000-0003-1075-9574en_US
dc.authorid0000-0001-8210-9701en_US
dc.authorid0000-0003-4219-8054en_US
dc.authorid0000-0001-9335-7348en_US
dc.authorid0000-0001-7310-7800en_US
dc.authorid0000-0002-6045-8342en_US
dc.contributor.authorYunusoğlu, Oruç
dc.contributor.authorDemirkol, Muhammed Hamdi
dc.contributor.authorBerköz, Mehmet
dc.contributor.authorSağmanlıgil, Vedat
dc.contributor.authorOto, Gökhan
dc.contributor.authorÖzdemir, Hülya
dc.date.accessioned2023-06-13T08:33:03Z
dc.date.available2023-06-13T08:33:03Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractCurrent pharmacotherapies for nicotine abuse are few and relatively inefficient demonstrating the need for the development of new, effective remedies. Moxidectin is used as an anti-parasitic agent in both animals and humans, it also activates GABA receptors. The objective of the present investigation was to study the effect of moxidectin on nicotine-induced conditioned place preference (CPP) in male Swiss mice. Intraperitoneal (i.p.) route was used for nicotine (0.5mg/kg) administration for a 3-day conditioning program. The influences of moxidectin on the reinforcing characteristics of nicotine were tested in mice given i.p. treatment of moxidectin (5 and 10mg/kg) 30 minutes prior to per nicotine administration. CPP was extinguished by repeated testing, through which conditioned mice were daily given two doses of moxidectin (5 and 10mg/kg, i.p.). Subsequently, the potency of moxidectin in blocking the reinstatement of CPP provoked by priming given low-dose nicotine (0.1mg/kg, i.p.) was also evaluated. Moxidectin treatment illustrated a reserve of acquisition of nicotine-induced CPP. It was reduced priming nicotine-induced reinstatement and accelerated the extinction of CPP. Relatively nicotine enhanced the locomotor, motor activity but was not statistically significant. In conclusion, the outcomes demonstrate the potential for the development of moxidectin as a new pharmacotherapy for the treatment of nicotine addiction. (C) 2021 The Authors. Published by IASE.en_US
dc.identifier.citationEkici, A., Gürbüz, E., Berköz, M., Türkmen, Ö., Başbuğan, Y., & Yunusoğlu, O. (2022). Investigation of the impact of antiparasitic drug moxidectin on the rewarding effects of alcohol. General Physiology & Biophysics, 41(3).en_US
dc.identifier.doi10.21833/ijaas.2021.12.014
dc.identifier.endpage125en_US
dc.identifier.issn2313-626X
dc.identifier.issn2313-3724
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85120586451en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage117en_US
dc.identifier.urihttp://dx.doi.org/10.21833/ijaas.2021.12.014
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11107
dc.identifier.volume8en_US
dc.identifier.wosWOS:000811310900014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYunusoğlu, Oruç
dc.language.isoenen_US
dc.publisherInst Advanced Science Extensionen_US
dc.relation.ispartofInternational Journal of Advanced and Applied Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNicotine Addictionen_US
dc.subjectMoxidectinen_US
dc.subjectConditioned Place Preferenceen_US
dc.titleThe effects of moxidectin nicotine-conditioned cue on nicotine-seeking behavior in miceen_US
dc.typeArticleen_US

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