The effects of moxidectin nicotine-conditioned cue on nicotine-seeking behavior in mice
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Inst Advanced Science Extension
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Current pharmacotherapies for nicotine abuse are few and relatively inefficient demonstrating the need for the development of new, effective remedies. Moxidectin is used as an anti-parasitic agent in both animals and humans, it also activates GABA receptors. The objective of the present investigation was to study the effect of moxidectin on nicotine-induced conditioned place preference (CPP) in male Swiss mice. Intraperitoneal (i.p.) route was used for nicotine (0.5mg/kg) administration for a 3-day conditioning program. The influences of moxidectin on the reinforcing characteristics of nicotine were tested in mice given i.p. treatment of moxidectin (5 and 10mg/kg) 30 minutes prior to per nicotine administration. CPP was extinguished by repeated testing, through which conditioned mice were daily given two doses of moxidectin (5 and 10mg/kg, i.p.). Subsequently, the potency of moxidectin in blocking the reinstatement of CPP provoked by priming given low-dose nicotine (0.1mg/kg, i.p.) was also evaluated. Moxidectin treatment illustrated a reserve of acquisition of nicotine-induced CPP. It was reduced priming nicotine-induced reinstatement and accelerated the extinction of CPP. Relatively nicotine enhanced the locomotor, motor activity but was not statistically significant. In conclusion, the outcomes demonstrate the potential for the development of moxidectin as a new pharmacotherapy for the treatment of nicotine addiction. (C) 2021 The Authors. Published by IASE.
Açıklama
Anahtar Kelimeler
Nicotine Addiction, Moxidectin, Conditioned Place Preference
Kaynak
International Journal of Advanced and Applied Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
8
Sayı
12
Künye
Ekici, A., Gürbüz, E., Berköz, M., Türkmen, Ö., Başbuğan, Y., & Yunusoğlu, O. (2022). Investigation of the impact of antiparasitic drug moxidectin on the rewarding effects of alcohol. General Physiology & Biophysics, 41(3).
