Antiemetic effects of dexamethasone and ondansetron combination during cesarean sections under spinal anaesthesia

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dc.authorid0000-0002-1630-2033en_US
dc.contributor.authorDemirhan, Abdullah
dc.contributor.authorTekelioğlu, Yaşar Ümit
dc.contributor.authorAkkaya, Akcan
dc.contributor.authorÖzlü, Tülay
dc.contributor.authorYıldız, İsa
dc.contributor.authorBayır, Hakan
dc.contributor.authorKoçoğlu, Hasan
dc.contributor.authorDuran, Bülent
dc.date.accessioned2021-06-23T19:35:00Z
dc.date.available2021-06-23T19:35:00Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Nausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of post-delivery intraoperative nausea and vomiting (IONV) during CS under spinal anesthesia. Objective: To compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the single use of each agent to decrease the incidence of postdelivery IONV during CS under spinal anesthesia. Methods: A randomized, prospective, double blind study was performed on 90 patients undergoing planned CS under spinal anesthesia. Patients received 4mg ondansetron in Group O, 8mg dexamethasone in GroupD, 4mg ondansetron+8mg dexamethasone in Group OD intravenously within 1-2 minutes after the umbilical cord was clamped. Frequency of postdelivery IONV episodes was recorded. Results: A total of 86 eligible patients were included in the study. There were 29 patients in Group O, 29 patients in Group D and 28 patients in Group OD. There were no statistically significant difference between the groups in terms of baseline characteristics and intraoperative managements. Frequency of intraoperative nausea, retching and vomiting experiences were similar between the groups(p>0.05). Conclusion: Single dose 4mg ondansetron, 8mg dexamethasone, or combined use of 8mg dexamethasone+4mg ondansetron, given intravenously is all effective agents for the control of postdelivery IONV. Combined use of dexamethasone and ondansetron for the same indication does not seem to increase the antiemetic efficacy.en_US
dc.identifier.doi10.4314/ahs.v13i2.39
dc.identifier.endpage482en_US
dc.identifier.issn1680-6905
dc.identifier.issn1729-0503
dc.identifier.issue2en_US
dc.identifier.pmid24235952en_US
dc.identifier.scopus2-s2.0-84883672117en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage475en_US
dc.identifier.urihttps://doi.org/10.4314/ahs.v13i2.39
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7685
dc.identifier.volume13en_US
dc.identifier.wosWOS:000325695600040en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemirhan, Abdullah
dc.institutionauthorTekelioğlu, Yaşar Ümit
dc.institutionauthorAkkaya, Akcan
dc.institutionauthorÖzlü, Tülay
dc.institutionauthorYıldız, İsa
dc.institutionauthorBayır, Hakan
dc.institutionauthorKoçoğlu, Hasan
dc.institutionauthorDuran, Bülent
dc.language.isoenen_US
dc.publisherMakerere Univ, Fac Meden_US
dc.relation.ispartofAfrican Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEmesisen_US
dc.subjectNausea and Vomitingen_US
dc.subjectIntraoperativeen_US
dc.subjectOndansetronen_US
dc.subject5-HT3 Antagonistsen_US
dc.subjectDexamethasoneen_US
dc.titleAntiemetic effects of dexamethasone and ondansetron combination during cesarean sections under spinal anaesthesiaen_US
dc.typeArticleen_US

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